Evidence map›Paper›PMID 36220339›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Therapeutic Nanocarriers Inhibit Chemotherapy-Induced Breast Cancer Metastasis.

Tianyu Li, Tolulope Akinade, Jie Zhou, Hongxia Wang, Qisong Tong, Siyu He, Emily Rinebold, Luis E Valencia Salazar, Divya Bhansali, Yiling Zhong and 4 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Cell-Free DNA-Based Theranostics for Inflammatory Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Emerging Nanozyme Strategies for Precision Breast Cancer Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. PARBiomaterials · 2025
    Article
  16. Bioinspired exosome-SiOTheranostics · 2025
    Article
  17. Curcumin nanoparticles in heat stroke management.Journal of nanobiotechnology · 2024
    Article
  18. Enhanced anti-tumor therapy for hepatocellular carcinoma via sorafenib and KIAA1199-siRNA co-delivery liposomes.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Tianyu LiDepartment of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.ORCID 0000-0002-3719-1459
Tolulope AkinadeGraduate Program in Cellular, Molecular and Biomedical Studies, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10027, USA.
Jie ZhouDepartment of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Hongxia WangDepartment of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Qisong TongSchool of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, P. R. China.
Siyu HeDepartment of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Emily RineboldDepartment of Pathology & Cell Biology, Department of Medicine (Division of Digestive and Liver Diseases), Herbert Irving Comprehensive Cancer Center (HICCC) and Columbia Stem Cell Initiative (CSCI), Columbia University, New York, NY, 10032, USA.
Luis E Valencia SalazarDepartment of Pathology & Cell Biology, Department of Medicine (Division of Digestive and Liver Diseases), Herbert Irving Comprehensive Cancer Center (HICCC) and Columbia Stem Cell Initiative (CSCI), Columbia University, New York, NY, 10032, USA.
Divya BhansaliDepartment of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Yiling ZhongDepartment of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Jing RuanDepartment of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Jinzhi DuSchool of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, P. R. China.
Piero DalerbaDepartment of Pathology & Cell Biology, Department of Medicine (Division of Digestive and Liver Diseases), Herbert Irving Comprehensive Cancer Center (HICCC) and Columbia Stem Cell Initiative (CSCI), Columbia University, New York, NY, 10032, USA.
Kam W LeongDepartment of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.ORCID 0000-0002-8133-4955
Columbia University · USColumbia University Irving Medical Center · USSouth China University of Technology · CNGuangzhou Medical University Cancer Hospital · CN

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
NRSA Training CoreTL1TR001875 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPANN, MARISA N, TAYLOR, JACQUELYN Y · 2016 to 2025
$8.9M
Engineering Polymers to Scavenge DAMPs in Arthritis and LupusR01AR073935 · NIAMS · DUKE UNIVERSITY · PI LEONG, KAM W, SULLENGER, BRUCE ALAN · 2018 to 2022
$3.3M
Design and Application of Cationic Nanocarriers to Inhibit Breast Cancer Progression in Primary and Metastatic SitesF31CA257399 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AKINADE, TOLULOPE OLATOKUNBO · 2021 to 2023
$118k
Medical Scientific Research Foundation of Guangdong Province B2019094National Natural Science Foundation of China 82002776NCATS NIH HHS TL1 TR001875NCATS NIH HHS UL1 TR001873NCI NIH HHS F31 CA257399NCI NIH HHS P30 CA013696NIAMS NIH HHS R01 AR073935U.S. DOD USAMR W81XWH1910463U.S. DOD W81XWH1910464U.S. NIH F31CA257399U.S. NIH P30-CA013696U.S. NIH RO1AR073935U.S. NIH TL1-TR001875
6 · The paper itself

Abstract

Chemotherapy, although effective against primary tumors, may promote metastasis by causing the release of proinflammatory factors from damaged cells. Here, polymeric nanoparticles that deliver chemotherapeutics and scavenge proinflammatory factors simultaneously to inhibit chemotherapy-induced breast cancer metastasis are developed. The cationic nanoparticles can adsorb cell-free nucleic acids (cfNAs) based on charge-charge interaction, which downregulates the expression of Toll-like receptors and then reduces the secretion of inflammatory cytokines. Through in vitro structural optimization, cationic polyamidoamine (PAMAM) dendrimers modified with drug-binding dodecyl groups and diethylethanolamine surface groups (PAMAM-G3-C12

Indexed as

Antineoplastic AgentsNanoparticlesNeoplasmsAnimalsCytokinesMicePaclitaxelPolyaminesAntineoplastic AgentsCytokinesPaclitaxelPoly(amidoamine)Polyaminesbreast cancercell-free nucleic acidchemotherapymetastasisnanocarrierscavenger

Identifiers

PMID36220339
PMCPMC9685442
OpenAlexW4304607631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.