Evidence map›Paper›PMID 36220001›Full record

ReviewCurrent opinion in genetics & development2022

Mechanisms of regulatory evolution in yeast.

Mohammad A Siddiq, Patricia J Wittkopp

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles.Annual review of cell and developmental biology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Contributions of mutation and selection to regulatory variation: lessons from thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mohammad A SiddiqDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address: https://twitter.com/richlopez41.
Patricia J WittkoppDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA; Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address: wittkopp@umich.edu.
Twitter (United States) · USUniversity of Michigan · US

Funding

University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Genetic mechanisms and evolutionary processes underlying diversity within and between speciesR35GM118073 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WITTKOPP, PATRICIA JEAN · 2016 to 2025
$4.1M
Genetic mechanisms and coevolutionary interactions in the evolution of gene expression divergenceF32CA261115 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIDDIQ, MOHAMMAD · 2021 to 2023
$210k
NCI NIH HHS F32 CA261115NHGRI NIH HHS T32 HG000040NIGMS NIH HHS R35 GM118073
6 · The paper itself

Abstract

Studies of regulatory variation in yeast - at the level of new mutations, polymorphisms within a species, and divergence between species - have provided great insight into the molecular and evolutionary processes responsible for the evolution of gene expression in eukaryotes. The increasing ease with which yeast genomes can be manipulated and expression quantified in a high-throughput manner has recently accelerated mechanistic studies of cis- and trans-regulatory variation at multiple evolutionary timescales. These studies have, for example, identified differences in the properties of cis- and trans-acting mutations that affect their evolutionary fate, experimentally characterized the molecular mechanisms through which cis- and trans-regulatory variants act, and illustrated how regulatory networks can diverge between species with or without changes in gene expression.

Indexed as

Evolution, MolecularSaccharomyces cerevisiaeGenome

Identifiers

PMID36220001
PMCPMC10117219
OpenAlexW4303579760

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.