Evidence map›Paper›PMID 36219950›Full record

ReviewCurrent opinion in neurobiology2022

Reconciling neuronal representations of schema, abstract task structure, and categorization under cognitive maps in the entorhinal-hippocampal-frontal circuits.

Kei M Igarashi, Jason Y Lee, Heechul Jun

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current opinion in neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Lateral entorhinal cortex afferents reconfigure the activity in piriform cortex circuits.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kei M IgarashiDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine. Electronic address: kei.igarashi@uci.edu.
Jason Y LeeDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine.
Heechul JunDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Understanding neural circuits for associative memory in the lateral entorhinal cortexR01MH121736 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI IGARASHI, KEI M · 2019 to 2023
$2.3M
Cell-type-specific vulnerability of the entorhinal cortex in Alzheimer's diseaseR01AG066806 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI IGARASHI, KEI M · 2020 to 2024
$2.0M
Understanding the role of gamma oscillations underlying entorhinal cortex dysfunction in Alzheimer’s diseaseR01AG063864 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI IGARASHI, KEI M · 2019 to 2023
$1.9M
Circuit mechanisms underlying associative memory impairment in knock-in Alzheimer's modelF31AG074650 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LEE, JASON YEN SUN · 2022 to 2023
$86k
Investigating spatial representation in hippocampal entorhinal circuit of knock in Alzheimer's modelF31AG069500 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JUN, HEECHUL · 2020 to 2021
$75k
NIA NIH HHS F31 AG069500NIA NIH HHS F31 AG074650NIA NIH HHS R01 AG063864NIA NIH HHS R01 AG066806NIGMS NIH HHS T32 GM008620NIMH NIH HHS R01 MH121736
6 · The paper itself

Abstract

Learning leads to a neuronal representation of acquired knowledge. This idea of knowledge representation was traditionally developed as a "cognitive map" of spatial memory represented in the hippocampus. The framework of cognitive mapping has been extended in the past decade to include not only spatial memory, but also non-spatial factual and temporal memory. Following this conceptual advancement, a line of recent neurophysiological research discovered such knowledge representations not only in the hippocampus, but also in the entorhinal cortex and frontal cortex. Although the distinct terms "cognitive map," "schema," "abstract task structure" or "categorization" were used in these studies, it is likely that these terms can be reconciled as a common mechanism of learned knowledge representations. Future experimental work will be required to differentiate the parametric nature of knowledge representations across brain areas.

Indexed as

Entorhinal CortexHippocampusCognitionLearningNeurons

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.