ArticleJournal of critical care2022
The impact of obesity on the outcome of severe SARS-CoV-2 ARDS in a high volume ECMO centre: ECMO and corticosteroids support the obesity paradox.
Article in Journal of critical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Impact of obesity on outcomes of extracorporeal membrane oxygenation support: a systematic review and meta-analysis.BMC pulmonary medicine · 2024Pooled it
- The impact of remdesivir on renal and liver functions in severe COVID-19 patients with presence of viral load.Scientific reports · 2025Article
- Obesity and Extracorporeal Membrane Oxygenation.Respiratory care · 2024Review
- Extracorporeal Membrane Oxygenation for Septic Shock in Adults and Children: A Narrative Review.Journal of clinical medicine · 2023Review
- Prognostic Impact of Serial Imaging in Severe Acute Respiratory Distress Syndrome on the Extracorporeal Membrane Oxygenation.Journal of clinical medicine · 2023Article
- Mortality in Patients with Obesity and Acute Respiratory Distress Syndrome Receiving Extracorporeal Membrane Oxygenation: The Multicenter ECMObesity Study.American journal of respiratory and critical care medicine · 2023Article
- Long-Term Outcomes of Extracorporeal Life Support in Respiratory Failure.Journal of clinical medicine · 2023Review
- Obesity Paradox in Lung Diseases: What Explains It?Obesity facts · 2023Review
- The Importance of COVID-19/Influenza Vaccines Co-Administration: An Essential Public Health Tool.Infectious disease reports · 2022Article
- Role of the 1Journal of preventive medicine and hygiene · 2022Article
Corrections and comments
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Authors and funding
32 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim was to verify the impact of obesity on the long-term outcome of patients with severe SARS-CoV-2 ARDS. MATERIALS AND
methodsThe retrospective study included patients admitted to the high-volume ECMO centre between March 2020 and March 2022. The impact of body mass index (BMI), co-morbidities and therapeutic measures on the short and 90-day outcomes was analysed.
results292 patients were included, of whom 119(40.8%) were treated with veno-venous ECMO cannulated mostly (73%) in a local hospital. 58.5% were obese (64.7% on ECMO), the ECMO was most frequent in BMI > 40(49%). The ICU mortality (36.8% for obese vs 33.9% for the non-obese, p = 0.58) was related to ECMO only for the non-obese (p = 0.04). The 90-day mortalities (48.5% obese vs 45.5% non-obese, p = 0.603) of the ECMO and non-ECMO patients were not significantly influenced by BMI (p = 0.47, p = 0.771, respectively). The obesity associated risk factors for adverse outcome were age <50 (RR 2.14) and history of chronic immunosuppressive therapy (RR 2.11, p = 0.009). The higher dosage of steroids (RR 0.57, p = 0.05) associated with a better outcome.
conclusionsThe high incidence of obesity was not associated with worse short and long-term outcomes. ECMO in obese patients together with the use of steroids in the later stage of ARDS may improve survival.
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