Evidence map›Paper›PMID 36219802›Full record

ArticleNeurology2022

Longitudinal Effects of Combination Antiretroviral Therapy on Cognition and Neuroimaging Biomarkers in Treatment-Naive People With HIV.

Miriam T Weber, Alan Finkelstein, Md Nasir Uddin, Elizabeth Asiago Reddy, Roberto C Arduino, Lu Wang, Madalina E Tivarus, Jianhui Zhong, Xing Qiu, Giovanni Schifitto

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Miriam T WeberFrom the Departments of Neurology (M.T.W., M.N.U., G.S.), Obstetrics and Gynecology (M.T.W.), and Biomedical Engineering (A.F., J.Z.), University of Rochester, NY; Department of Infectious Disease (E.A.R.), SUNY Upstate Medical Center, Syracuse, NY; Department of Internal Medicine (R.C.A.), McGovern Medical School at The University of Texas Health Science Center at Houston; Departments of Biostatistics and Computational Biology (L.W., X.Q., G.S.), Imaging Sciences (M.E.T., J.Z.), and Neuroscience (M.E.T.), University of Rochester Medical Center; and Department of Physics and Astronomy (J.Z.), University of Rochester, NY. miriam_weber@urmc.rochester.edu.
Alan FinkelsteinFrom the Departments of Neurology (M.T.W., M.N.U., G.S.), Obstetrics and Gynecology (M.T.W.), and Biomedical Engineering (A.F., J.Z.), University of Rochester, NY; Department of Infectious Disease (E.A.R.), SUNY Upstate Medical Center, Syracuse, NY; Department of Internal Medicine (R.C.A.), McGovern Medical School at The University of Texas Health Science Center at Houston; Departments of Biostatistics and Computational Biology (L.W., X.Q., G.S.), Imaging Sciences (M.E.T., J.Z.), and Neuroscience (M.E.T.), University of Rochester Medical Center; and Department of Physics and Astronomy (J.Z.), University of Rochester, NY.
Md Nasir UddinFrom the Departments of Neurology (M.T.W., M.N.U., G.S.), Obstetrics and Gynecology (M.T.W.), and Biomedical Engineering (A.F., J.Z.), University of Rochester, NY; Department of Infectious Disease (E.A.R.), SUNY Upstate Medical Center, Syracuse, NY; Department of Internal Medicine (R.C.A.), McGovern Medical School at The University of Texas Health Science Center at Houston; Departments of Biostatistics and Computational Biology (L.W., X.Q., G.S.), Imaging Sciences (M.E.T., J.Z.), and Neuroscience (M.E.T.), University of Rochester Medical Center; and Department of Physics and Astronomy (J.Z.), University of Rochester, NY.
Elizabeth Asiago ReddyFrom the Departments of Neurology (M.T.W., M.N.U., G.S.), Obstetrics and Gynecology (M.T.W.), and Biomedical Engineering (A.F., J.Z.), University of Rochester, NY; Department of Infectious Disease (E.A.R.), SUNY Upstate Medical Center, Syracuse, NY; Department of Internal Medicine (R.C.A.), McGovern Medical School at The University of Texas Health Science Center at Houston; Departments of Biostatistics and Computational Biology (L.W., X.Q., G.S.), Imaging Sciences (M.E.T., J.Z.), and Neuroscience (M.E.T.), University of Rochester Medical Center; and Department of Physics and Astronomy (J.Z.), University of Rochester, NY.
Roberto C ArduinoFrom the Departments of Neurology (M.T.W., M.N.U., G.S.), Obstetrics and Gynecology (M.T.W.), and Biomedical Engineering (A.F., J.Z.), University of Rochester, NY; Department of Infectious Disease (E.A.R.), SUNY Upstate Medical Center, Syracuse, NY; Department of Internal Medicine (R.C.A.), McGovern Medical School at The University of Texas Health Science Center at Houston; Departments of Biostatistics and Computational Biology (L.W., X.Q., G.S.), Imaging Sciences (M.E.T., J.Z.), and Neuroscience (M.E.T.), University of Rochester Medical Center; and Department of Physics and Astronomy (J.Z.), University of Rochester, NY.
Lu WangFrom the Departments of Neurology (M.T.W., M.N.U., G.S.), Obstetrics and Gynecology (M.T.W.), and Biomedical Engineering (A.F., J.Z.), University of Rochester, NY; Department of Infectious Disease (E.A.R.), SUNY Upstate Medical Center, Syracuse, NY; Department of Internal Medicine (R.C.A.), McGovern Medical School at The University of Texas Health Science Center at Houston; Departments of Biostatistics and Computational Biology (L.W., X.Q., G.S.), Imaging Sciences (M.E.T., J.Z.), and Neuroscience (M.E.T.), University of Rochester Medical Center; and Department of Physics and Astronomy (J.Z.), University of Rochester, NY.
Madalina E TivarusFrom the Departments of Neurology (M.T.W., M.N.U., G.S.), Obstetrics and Gynecology (M.T.W.), and Biomedical Engineering (A.F., J.Z.), University of Rochester, NY; Department of Infectious Disease (E.A.R.), SUNY Upstate Medical Center, Syracuse, NY; Department of Internal Medicine (R.C.A.), McGovern Medical School at The University of Texas Health Science Center at Houston; Departments of Biostatistics and Computational Biology (L.W., X.Q., G.S.), Imaging Sciences (M.E.T., J.Z.), and Neuroscience (M.E.T.), University of Rochester Medical Center; and Department of Physics and Astronomy (J.Z.), University of Rochester, NY.ORCID 0000-0001-7481-5913
Jianhui ZhongFrom the Departments of Neurology (M.T.W., M.N.U., G.S.), Obstetrics and Gynecology (M.T.W.), and Biomedical Engineering (A.F., J.Z.), University of Rochester, NY; Department of Infectious Disease (E.A.R.), SUNY Upstate Medical Center, Syracuse, NY; Department of Internal Medicine (R.C.A.), McGovern Medical School at The University of Texas Health Science Center at Houston; Departments of Biostatistics and Computational Biology (L.W., X.Q., G.S.), Imaging Sciences (M.E.T., J.Z.), and Neuroscience (M.E.T.), University of Rochester Medical Center; and Department of Physics and Astronomy (J.Z.), University of Rochester, NY.
Xing QiuFrom the Departments of Neurology (M.T.W., M.N.U., G.S.), Obstetrics and Gynecology (M.T.W.), and Biomedical Engineering (A.F., J.Z.), University of Rochester, NY; Department of Infectious Disease (E.A.R.), SUNY Upstate Medical Center, Syracuse, NY; Department of Internal Medicine (R.C.A.), McGovern Medical School at The University of Texas Health Science Center at Houston; Departments of Biostatistics and Computational Biology (L.W., X.Q., G.S.), Imaging Sciences (M.E.T., J.Z.), and Neuroscience (M.E.T.), University of Rochester Medical Center; and Department of Physics and Astronomy (J.Z.), University of Rochester, NY.ORCID 0000-0002-2330-3544
Giovanni SchifittoFrom the Departments of Neurology (M.T.W., M.N.U., G.S.), Obstetrics and Gynecology (M.T.W.), and Biomedical Engineering (A.F., J.Z.), University of Rochester, NY; Department of Infectious Disease (E.A.R.), SUNY Upstate Medical Center, Syracuse, NY; Department of Internal Medicine (R.C.A.), McGovern Medical School at The University of Texas Health Science Center at Houston; Departments of Biostatistics and Computational Biology (L.W., X.Q., G.S.), Imaging Sciences (M.E.T., J.Z.), and Neuroscience (M.E.T.), University of Rochester Medical Center; and Department of Physics and Astronomy (J.Z.), University of Rochester, NY.
SUNY Upstate Medical University · US

Funding

Training in HIV Replication and PathogenesisT32AI049815 · NIAID · UNIVERSITY OF ROCHESTER · PI WEDEKIND, JOSEPH E · 2001 to 2020
$3.5M
Chronic Exposure to cART Predispose Older HIV Infected Individuals to CNS Injury?R01MH099921 · NIMH · UNIVERSITY OF ROCHESTER · PI SCHIFITTO, GIOVANNI · 2013 to 2017
$3.0M
NIAID NIH HHS T32 AI049815NIMH NIH HHS R01 MH099921
6 · The paper itself

Abstract

BACKGROUND AND

objectivesWhile combination antiretroviral therapy (cART) has dramatically increased the life expectancy of people with HIV (PWH), nearly 50% develop HIV-associated neurocognitive disorders. This may be due to previously uncontrolled HIV viral replication, immune activation maintained by residual viral replication or activation from other sources, or cART-associated neurotoxicity. The aim of this study was to determine the effect of cART on cognition and neuroimaging biomarkers in PWH before and after initiation of cART compared with that in HIV-negative controls (HCs) and HIV elite controllers (ECs) who remain untreated.

methodsWe recruited 3 groups of participants from the University of Rochester, McGovern Medical School, and SUNY Upstate Medical University: (1) ART treatment-naive PWH; (2) age-matched HCs; and (3) ECs. Participants underwent brain MRI and clinical and neuropsychological assessments at baseline, 1 year, and 2 years. PWH were also assessed 12 weeks after initiating cART. Volumetric analysis and fractal dimensionality (FD) were calculated for cortical and subcortical regions. Mixed effect regressions examined the effect of group and imaging variables on cognition.

resultsWe enrolled 47 PWH, 58 HCs, and 10 ECs. At baseline, PWH had worse cognition and lower cortical volumes than HCs. Cognition improved after initiation of cART and remained stable over time. Greater cortical thickness was associated with better cognition at baseline; greater FD of parietal, temporal, and occipital lobes was associated with better cognition at baseline and longitudinally. At baseline, ECs had worse cognition, lower cortical thickness, and lower FD in all 4 lobes and caudate than PWH and HCs. Greater cortical thickness, hippocampal volumes, and FD of frontal, temporal, and occipital lobes were associated with better cognition longitudinally. DISCUSSION: Initiation of cART in PWH is associated with improvement in brain structure and cognition. However, significant differences persist over time when compared with HCs. Similar trends in ECs suggest that results are due to HIV infection rather than treatment. Stronger associations between cognition and FD suggest this imaging metric may be a more sensitive marker of neuronal injury than cortical thickness and volumetric measures.

Indexed as

Antiretroviral Therapy, Highly ActiveHIV InfectionsBiomarkersCognitionHumansNeuroimagingBiomarkers

Identifiers

PMID36219802
PMCPMC9519252
OpenAlexW4283320066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.