Evidence map›Paper›PMID 36219705›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

Effect of Malaria and Malaria Chemoprevention Regimens in Pregnancy and Childhood on Neurodevelopmental and Behavioral Outcomes in Children at 12, 24, and 36 Months: A Randomized Clinical Trial.

Paul Bangirana, Andrea L Conroy, Robert O Opoka, Margaret Semrud-Clikeman, Jeong H Jang, Claire Apayi, Abel Kakuru, Mary K Muhindo, Michael K Georgieff, Grant M Dorsey and 3 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02557425 (Prophylaxis Against Malaria to Enhance Child Development), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02557425 completednot on this map

Prophylaxis Against Malaria to Enhance Child Development

TypeobservationalSponsorIndiana UniversityRan2015 to 2021Enrolled272ConditionsNeurobehavioral ManifestationsArmsNo intervention in PROTECT
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Paul BangiranaDepartment of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda.
Andrea L ConroyRyan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis.
Robert O OpokaDepartment of Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
Margaret Semrud-ClikemanDepartment of Pediatrics, University of Minnesota, Minnesota, USA.
Jeong H JangUnderwood International College and Department of Applied Statistics, Yonsei University, Seoul, Korea.
Claire ApayiInfectious Diseases Research Collaboration, Kampala, Uganda.
Abel KakuruInfectious Diseases Research Collaboration, Kampala, Uganda.
Mary K MuhindoInfectious Diseases Research Collaboration, Kampala, Uganda.
Michael K GeorgieffDepartment of Pediatrics, University of Minnesota, Minnesota, USA.
Grant M DorseyDepartment of Medicine, University of California, California, USA.
Moses R KamyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Diane HavlirDepartment of Medicine, University of California, California, USA.
Chandy C JohnRyan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis.ORCID 0000-0002-1634-1411
Infectious Diseases Research Collaboration · UGIndiana University School of MedicineMakerere University · UGUniversity of Minnesota · USYonsei University · KR

Funding

Prophylaxis against malaria to enhance child developmentR01HD086124 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI BANGIRANA, PAUL, JOHN, CHANDY C. · 2016 to 2020
$2.0M
NICHD NIH HHS R01 HD086124
6 · The paper itself

Abstract

backgroundMalaria in pregnancy has been associated with worse cognitive outcomes in children, but its association with behavioral outcomes and the effectiveness of malaria chemoprevention on child neurodevelopment are not well characterized.

methodsTo determine if more effective malaria chemoprevention in mothers and their children results in better neurodevelopment, 305 pregnant women were randomly assigned to 3 doses of sulfadoxine-pyrimethamine, 3 doses of dihydroartemisinin-piperaquine (DP), or monthly DP during pregnancy, and their 293 children were assigned to DP every 3 months or monthly DP from 2 to 24 months of age. Cognition, language, and motor function were assessed at 12, 24. and 36 months of age, and attention, memory, behavior, and executive function were assessed at 24 and 36 months of age.

resultsChildren of mothers with versus without malaria in pregnancy had worse scores on cognitive, behavioral, and executive function outcomes at 24 months. Clinical malaria in children within the first 12 months was similarly associated with poorer scores in behavior and executive function at 24 months, language at 24 and 36 months, and motor function scores at 36 months. However, more effective malaria chemoprevention in the mothers and children was not associated with better outcomes.

conclusionsMalaria in pregnancy was associated with worse cognitive, behavioral, and executive function scores in affected children, but more effective malaria chemoprevention measures did not result in better outcomes. Malaria chemoprevention prior to and early in gestation and with even higher efficacy in mothers and children may be required to prevent neurodevelopmental impairment in children. Clinical Trials Registration. NCT02557425.

Indexed as

AntimalarialsArtemisininsMalariaQuinolinesChemopreventionChildDrug CombinationsFemaleHumansPregnancyPyrimethamineSulfadoxineAntimalarialsArtemisininsartenimolDrug CombinationsPyrimethamineQuinolinesSulfadoxinechemopreventiondevelopmentmalariapregnancy

Identifiers

PMID36219705
PMCPMC10169410
OpenAlexW4304207186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.