Evidence map›Paper›PMID 36219485›Full record

ArticleCancer2022

Patient outcomes following implementation of an enhanced recovery after surgery pathway for patients with metastatic spine tumors.

Vikram B Chakravarthy, Ilya Laufer, Anubhav G Amin, Marc A Cohen, Anne S Reiner, Cindy Vuong, Petal-Ann S Persaud, Lisa M Ruppert, Vinay G Puttanniah, Anoushka M Afonso and 5 more

Open access · greenAbstract read
In one paragraph

Article in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. A critical appraisal of clinical practice guidelines on surgical treatments for spinal metastasis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
    Pooled it
  3. Trial
  4. Dose-response relationship between enhanced recovery protocol adherence and outcomes in geriatric spine metastasis surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  5. Article
  6. Trends and postoperative complications of spinal metastasis surgery in Thailand between 2015 and 2024: a nationwide retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Vikram B ChakravarthyDepartment of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0003-0081-6571
Ilya LauferNeurological Surgery, New York University Medical Center, New York, New York, USA.
Anubhav G AminDepartment of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Marc A CohenSurgery (Head and Neck), Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-6104-7967
Anne S ReinerDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-1258-6112
Cindy VuongDepartment of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Petal-Ann S PersaudDepartment of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Lisa M RuppertRehabilitation Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Vinay G PuttanniahDepartment of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Anoushka M AfonsoDepartment of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Van S TsuiDepartment of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jess W BrallierDepartment of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Vivek T MalhotraDepartment of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Mark H BilskyDepartment of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ori BarzilaiDepartment of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-4037-8716
Memorial Sloan Kettering Cancer Center · USNeurological Surgery · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundMetastatic spine tumor surgery consists of palliative operations performed on frail patients with multiple medical comorbidities. Enhanced recovery after surgery (ERAS) programs involve an evidence-based, multidisciplinary approach to improve perioperative outcomes. This study presents clinical outcomes of a metastatic spine tumor ERAS pathway implemented at a tertiary cancer center.

methodsThe metastatic spine tumor ERAS program launched in April 2019, and data from January 2018 to May 2020 were reviewed. Measured outcomes included the following: hospital length of stay (LOS), time to ambulation, urinary catheter duration, time to resumption of diet, intraoperative fluid intake, estimated blood loss (EBL), and intraoperative and postoperative day 0-5 cumulative opioid use (morphine milligram equivalent [MME]).

resultsA total of 390 patients were included in the final analysis: 177 consecutive patients undergoing metastatic spine tumor surgery enrolled in the ERAS program and 213 consecutive pre-ERAS patients. Although the mean case durations were similar in the ERAS and pre-ERAS cohorts (265 vs. 274 min; p = .22), the ERAS cohort had decreased EBL (157 vs. 215 ml; p = .003), decreased postoperative day 0-5 cumulative mean opioid use (178 vs. 396 MME; p < .0001), earlier ambulation (mean, 34 vs. 57 h; p = .0001), earlier discontinuation of urinary catheters (mean, 36 vs. 56 h; p < .001), and shorter LOS (5.4 vs. 7.5 days; p < .0001).

conclusionsThe implementation of a multidisciplinary ERAS program designed for metastatic spine tumor surgery led to improved clinical quality metrics, including shorter hospitalizations and significant reductions in opioid consumption.

Indexed as

Enhanced Recovery After SurgeryAnalgesics, OpioidEndrinHumansLength of StayPostoperative ComplicationsRetrospective StudiesSpineAnalgesics, OpioidEndrinMMEERASmetastasesmetastatic epidural spinal cord compressionopioidseparation surgerySpineStereotactic Body Radiation Therapy

Identifiers

PMID36219485
PMCPMC10859187
OpenAlexW4304203566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.