ArticleMagnetic resonance in medicine2023
Time-dependent diffusivity and kurtosis in phantoms and patients with head and neck cancer.
Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- A Phase 2 Exploratory Trial Evaluating Computed Tomography-Based Midtreatment Nodal Response to Select for De-escalated Chemoradiation Therapy in the Definitive Management of p16+ Oropharyngeal Cancer.International journal of radiation oncology, biology, physics · 2026Trial
- Monte Carlo Assessment of Accuracy for Mean Kärger Model Water Exchange Rate Estimates From Diffusional Kurtosis Time Dependence.NMR in biomedicine · 2026Article
- Reduced NEXI protocol for the quantification of human gray matter microstructure on the Connectome 2.0 scanner.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Non-monotonic time- and frequency-dependent diffusion kurtosis in the human brain revealed by pulsed and oscillating gradient experiments.Magnetic resonance in medicine · 2025Article
- Correcting pulse duration effects in the diffusional kurtosis of the multi-compartment Kärger model.Magnetic resonance in medicine · 2025Article
- Quantitative Time-Dependent Diffusion MRI for Diagnosis and Aggressiveness Assessment of Endometrial Cancer: A Prospective Study.Korean journal of radiology · 2025Article
- Preventive effects of low-dose radiation and hypofractionated radiation plus anti-programmed cell death protein 1 on lung metastasis in breast cancer.Oncology research · 2025Article
- In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI.Science advances · 2024Article
- Multiparametric MRI for characterization of the tumour microenvironment.Nature reviews. Clinical oncology · 2024Review
- Technical note: hydrogel-based mimics of prostate cancer with matched relaxation, diffusion and kurtosis for validating multi-parametric MRI.Medical physics · 2024Article
- Diffusional kurtosis time dependence and the water exchange rate for the multi-compartment Kärger model.Magnetic resonance in medicine · 2024Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
purposeTo assess the reliability of measuring diffusivity, diffusional kurtosis, and cellular-interstitial water exchange time with long diffusion times (100-800 ms) using stimulated-echo DWI.
methodsTime-dependent diffusion MRI was tested on two well-established diffusion phantoms and in 5 patients with head and neck cancer. Measurements were conducted using an in-house diffusion-weighted STEAM-EPI pulse sequence with multiple diffusion times at a fixed TE on three scanners. We used the weighted linear least-squares fit method to estimate time-dependent diffusivity,
resultsDiffusivity measured by time-dependent STEAM-EPI measurements and commercial SE-EPI showed comparable results with R
conclusionsBased on two well-established diffusion phantoms, we found that time-dependent diffusion MRI measurements can provide stable diffusion and kurtosis values over a wide range of diffusion times and across multiple MRI systems. Moreover, estimation of cellular-interstitial water exchange time can be achieved using the Kärger model for the metastatic lymph nodes in patients with head and neck cancer.
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