Evidence map›Paper›PMID 36219382›Full record

ArticleMycopathologia2022

Interaction of Amiodarone with Azoles Against Aspergillus Planktonic Cells and Biofilms in vitro.

Zhimin Duan, Jianbo Tong, Nana Zheng, Rong Zeng, Yuzhen Liu, Min Li

Abstract read
PubMed Publisher
In one paragraph

Article in Mycopathologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zhimin Duan *Hospital for Skin Diseases (Institute of Dermatology), Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, Jiangsu, China.ORCID http://orcid.org/0000-0002-2698-5288
Jianbo Tong *Department of Dermatology, The First Affiliated Hospital of Nanchang University and Institute of Dermatology, Jiangxi Academy of Clinical Medical Sciences, No. 17 Yongwaizheng Street, Nanchang, 330001, Jiangxi, China.ORCID http://orcid.org/0000-0003-2722-8673
Nana ZhengHospital for Skin Diseases (Institute of Dermatology), Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, Jiangsu, China.ORCID http://orcid.org/0000-0002-8905-2346
Rong ZengHospital for Skin Diseases (Institute of Dermatology), Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, Jiangsu, China. zengrong2010@hotmail.com.ORCID http://orcid.org/0000-0003-3196-5406
Yuzhen LiuDepartment of Dermatology, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, 211100, Jiangsu, China. liuyuzhen409@126.com.ORCID http://orcid.org/0000-0002-1660-1578
Min LiHospital for Skin Diseases (Institute of Dermatology), Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, Jiangsu, China. limin@pumcderm.cams.cn.ORCID http://orcid.org/0000-0003-1330-2326
Chinese Academy of Medical Sciences & Peking Union Medical College · CNNanchang University · CNNanjing Jiangning Hospital · CN

Funding

National Natural Science Foundation of China 82103749National Natural Science Foundation of China 82173432
6 · The paper itself

Abstract

Aspergillus spp. is the most common clinical pathogen of invasive fungal infection with high mortality. Existing treatments for Aspergillus spp. infection are still inefficient and accompanied by drug resistance, so it is still urgent to find new treatment approaches. The antiarrhythmic drug amiodarone (AMD) has demonstrated antifungal activity against a range of fungi. This study evaluated the efficacy of AMD in combination with triazoles for Aspergillus spp. infection. We tested the combined effect of AMD and three triazole drugs, namely, itraconazole (ITR), voriconazole (VRC), and posaconazole (POS), on the planktonic cells and biofilms of 20 strains of Aspergillus spp. via a checkerboard microdilution assay derived from 96-well plate-based method. Our results reveal that the combination of AMD with ITR or POS against Aspergillus biofilms has synergistic fungicidal effects. By contrast, the combination of AMD with VRC exhibits no antagonistic and synergistic effects. In this way, the use of AMD in combination with ITR or POS could be an effective adjunctive treatment for Aspergillus spp. infection.

Indexed as

AmiodaroneAspergillosisAntifungal AgentsAspergillusAzolesBiofilmsItraconazoleMicrobial Sensitivity TestsPlanktonVoriconazoleAmiodaroneAntifungal AgentsAzolesItraconazoleVoriconazoleAmiodaroneAspergillusBiofilmsItraconazolePosaconazoleVoriconazole

Identifiers

PMID36219382
OpenAlexW4304187494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.