Evidence map›Paper›PMID 36219341›Full record

ArticleHormones (Athens, Greece)2022

Association between medication adherence and health-related quality of life of patients with diabetes.

Athanasios Chantzaras, John Yfantopoulos

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Article in Hormones (Athens, Greece), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  9. Fixed-Dose Combination Therapy as a Strategy to Improve Antidiabetic Medication Adherence in People with Type 2 Diabetes: A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Athanasios ChantzarasNational and Kapodistrian University of Athens, Athens, Greece.
John YfantopoulosSchool of Economics and Political Sciences, National and Kapodistrian University of Athens, 6 Themistokleous Street, 106 78, Athens, Greece. yfantopoulos@gmail.com.ORCID http://orcid.org/0000-0003-0424-6887

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose was to evaluate the association between medication adherence and health-related quality of life (HRQoL) of patients with diabetes.

methodsIn this cross-sectional study, a total of 518 patients were recruited from the outpatient departments of different general public and private hospitals in Greece during the COVID-19 pandemic using a consecutive sampling method. HRQoL was assessed with the EQ-5D-5L instrument and medication adherence with the corresponding subscale of the Adherence Starts with Knowledge 20 questionnaire. The relationship between HRQoL and adherence was explored by employing Spearman's correlations and multiple binary logistic and linear stepwise regressions using robust standard errors.

resultsA total of 15.1 and 1.9% of the patients reported that they had taken a medicine either more or less often than prescribed in the last month and week, respectively. Statistically significant but modest correlations of medication non-adherence with the EQ-5D index (rho =  - 0.223), EQ-VAS (rho =  - 0.230), and all the HRQoL domains (rho ranging from 0.211, for pain/discomfort, to 0.136, for mobility issues) were found. These significant associations persisted even after controlling for several other known potential factors of HRQoL in the multivariable analyses, except for the mobility and anxiety/depression dimensions.

conclusionMedication non-adherence appears to be independently associated with lower HRQoL and health levels in patients with diabetes. It is crucial to plan interventions to enhance medication adherence not only to obtain greater value from the available resources, but also to improve HRQoL of patients with diabetes.

Indexed as

COVID-19 Drug TreatmentDiabetes MellitusCross-Sectional StudiesHealth StatusHumansMedication AdherencePandemicsQuality of LifeSurveys and QuestionnairesComplianceDiabetes mellitusGreeceMedication adherenceQuality of life

Identifiers

PMID36219341
PMCPMC9552716

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.