Evidence map›Paper›PMID 36219324›Full record

ArticleCurrent microbiology2022

Prevalence and Seasonality of Clostridiodes difficile over 12 Years at a Tertiary Hospital in Brazil.

Adriane C Maestri, Paula K Ando, Gustavo Sarot, Fernanda de Castilho, Sonia M Raboni, Keite S Nogueira

Abstract read
PubMed Publisher
In one paragraph

Article in Current microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Adriane C MaestriLaboratório de Bacteriologia, Complexo Hospital de Clínicas da Universidade Federal do Paraná-Rua Padre Camargo, 280-Alto da Glória, CEP: 80.062-240, Curitiba, Paraná, Brazil.
Paula K AndoCurso de Medicina, Universidade Federal do Paraná-Rua Padre Camargo, 280-Alto da Glória, CEP: 80.062-240, Curitiba, Paraná, Brazil.
Gustavo SarotCurso de Medicina, Universidade Federal do Paraná-Rua Padre Camargo, 280-Alto da Glória, CEP: 80.062-240, Curitiba, Paraná, Brazil.
Fernanda de CastilhoPrograma de Pós-graduação em Microbiologia, Parasitologia e Patologia, Universidade Federal do Paraná, Centro Politécnico, Av. Cel. Francisco H. dos Santos, 100-Jardim das Américas, CEP-81531-980, Curitiba, Paraná, Brazil.
Sonia M RaboniPrograma de Pós-graduação em Medicina Interna e Ciências da Saúde, Universidade Federal do Paraná-Rua General Carneiro, 181-Alto da Glória, CEP-80060-900, Curitiba, Paraná, Brazil.
Keite S NogueiraLaboratório de Bacteriologia, Complexo Hospital de Clínicas da Universidade Federal do Paraná-Rua Padre Camargo, 280-Alto da Glória, CEP: 80.062-240, Curitiba, Paraná, Brazil. keite.nogueira@hc.ufpr.br.ORCID http://orcid.org/0000-0001-5655-9645
Hospital de Clínicas Universidade Federal do Paraná · BRUniversidade Federal do Paraná · BR

Funding

Fundação Araucária PPSUS 2015 edition
6 · The paper itself

Abstract

Clostridioides difficile is the main pathogen responsible for antibiotic-associated diarrhea in adults. Besides its challenging diagnosis, C. difficile infection (CDI) causes substantial morbidity and mortality. Commercially, there are assays with different targets and performances in sensitivity and specificity. The objectives of this study were to: (1) evaluate the prevalence and seasonal variability of CDI rates at a tertiary hospital in southern Brazil over 12 years and (2) determine the impact of using a two-step algorithm test in the laboratory diagnosis. Between January 2007 and May 2019, fecal samples from 2275 patients were analyzed in a cross-sectional study. Four commercial tests were adopted for the diagnosis of CDI, the immunochromatographic test for toxin A from 2007 to 2010; the enzyme-linked immunosorbent assay method for toxins A and B from 2011 to March 2017; and the rapid enzyme immunoassay (EIA) for GDH and toxins A and B, associated with a Polymerase Chain Reaction (PCR) for the toxin B gene from June 2017 to 2019. The annual prevalence was 8.7% from 2007 to March 2017, increasing between June 2017 and 2019 to 14.7% when the C. diff Quik Chek Complete + GeneXpert C. difficile (two-step algorithm) test was adopted. The number of samples (691) and percentage of CDI cases (10.5%) were higher in winter, but the difference has no statistical significance (P > 0.05). An accurate diagnosis and adequate knowledge of the local seasonality of CDI allow the effective implementation of prevention and control strategies for nosocomial CDI, in addition to effective treatment for patients.

Indexed as

Bacterial ToxinsClostridioides difficileClostridium InfectionsAdultAnti-Bacterial AgentsBacterial ProteinsBrazilCross-Sectional StudiesFecesGlutamate DehydrogenaseHumansPrevalenceSensitivity and SpecificityTertiary Care CentersAnti-Bacterial AgentsBacterial ProteinsBacterial ToxinsGlutamate Dehydrogenase

Identifiers

PMID36219324
OpenAlexW4304208598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.