Trial reportJournal of neurology2023
Efficacy and safety of very early mobilization after thrombolysis in acute ischemic stroke: a randomized clinical trial.
Trial report in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Preventive effects of early mobilisation on delirium incidence in critically ill patients: systematic review and meta-analysis.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Pooled it
- A systematic review and meta-analysis of clinical efficacy of early and late rehabilitation interventions for ischemic stroke.BMC neurology · 2024Pooled it
- Efficacy and safety of very early rehabilitation for acute ischemic stroke: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Application of an ERAS-based care bundle strategy in early rehabilitation care of patients with acute ischemic stroke.Aging clinical and experimental research · 2025Trial
- Effects of very early exercise on inflammatory markers and clinical outcomes in patients with ischaemic stroke- a randomized controlled trial.BMC neurology · 2025Trial
- Serum sCD40L and galectin-3 in the prognosis prediction of patients with acute ischemic stroke.Journal of medical biochemistry · 2026Article
- Effect of 5E rehabilitation management model on physical and psychological health of elderly patients with cerebral infarction: a randomized controlled trial.BMC nursing · 2026Article
- Time-Driven Activity-Based Costing Methodology for Cost Savings in the EMOTE-TNK Study.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026Article
- The Brain-Atrial Fibrillation-Recent Rehabilitation Axis: A Modern Approach.Healthcare (Basel, Switzerland) · 2026Review
- Risk factors and intervention strategies for lower extremity deep vein thrombosis after intravenous thrombolysis for acute ischemic stroke.Frontiers in cardiovascular medicine · 2026Article
- Efficacy of Early Mobilization in Stroke Patients in Relation to Quality of Life and Level of Dependency: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Very Early Rehabilitation After Treatment with Intravenous Thrombolysis for Mild Acute Ischemic Stroke.Neurology international · 2025Article
- Effect of PDCA-optimized good limb positioning on hemiparetic rehabilitation outcomes in acute cerebral infarction.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke has a deleterious impact on human health due to its high incidence, degree of disabling sequelae and mortality, constituting one of the main causes of death and disability worldwide.
objectivesThis study aimed to assess the efficacy and safety of very early mobilization (VEMG) after thrombolysis in functional recovery in patients with acute ischemic stroke.
methodsThe present study was an open, prospective, randomized study, with no blinded outcome, carried out in the stroke unit of a tertiary referral hospital located in Salvador-Bahia, Brazil. The primary outcome was the level of functional independence. Secondary outcomes were functional mobility, balance, complications within 7 days of hospitalization and 90 days after hospital discharge, and length of stay. OUTCOMES: A total of 104 patients with ischemic stroke who received thrombolytic treatment between August 2020 and July 2021 were prospectively recruited to the study. Of these, 51 patients received VEMG within 24 h of the ictus and another 53 patients receiving usual care (UCG) with mobilization 24 h after the ictus. When compared to the usual care, the VEMG group was not associated with a significant reduction in the risk of the primary outcome (relative risk [95% confidence intervals]: 0.74 [0.339-1.607]) or any of the secondary outcomes.
conclusionIn this study, the strategy of early mobilization after thrombolysis in ischemic stroke was safe, but without evidence of short-term benefit. Brazilian Registry of Clinical Trials under the registry (registry number: RBR-8bgcs3).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.