Evidence map›Paper›PMID 36219122›Full record

ArticleMicrobiology spectrum2022

Noncanonical Mismatch Repair Protein NucS Modulates the Emergence of Antibiotic Resistance in Mycobacterium abscessus.

Rosilene Fressatti Cardoso, Isabel Martín-Blecua, Vanessa Pietrowski Baldin, Jean Eduardo Meneguello, José Ramón Valverde, Jesús Blázquez, Alfredo Castañeda-García

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. The unique role ofmBio · 2026
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  4. Regulation of the Expression ofAntibiotics (Basel, Switzerland) · 2025
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  5. Vitamin BMicrobiology spectrum · 2024
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Rosilene Fressatti Cardoso *Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
Isabel Martín-Blecua *Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología CNB-CSIC, Madrid, Spain.
Vanessa Pietrowski BaldinDepartamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
Jean Eduardo MeneguelloDepartamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
José Ramón ValverdeDepartamento de Computación Científica, Centro Nacional de Biotecnología CNB-CSIC, Madrid, Spain.
Jesús BlázquezDepartamento de Biotecnología Microbiana, Centro Nacional de Biotecnología CNB-CSIC, Madrid, Spain.
Alfredo Castañeda-GarcíaDepartamento de Biotecnología Microbiana, Centro Nacional de Biotecnología CNB-CSIC, Madrid, Spain.ORCID 0000-0002-1441-6125
Centro Nacional de Biotecnología · ESUniversidade Estadual de Maringá · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NucS/EndoMS-dependent noncanonical mismatch repair (MMR) ensures the stability of genomic DNA in mycobacteria and acts as a guardian of the genome by preventing the accumulation of point mutations. In order to address whether the inactivation of noncanonical MMR could increase the acquisition of drug resistance by mutation, a Δ

Indexed as

Mycobacterium abscessusMycobacterium Infections, NontuberculousAminoglycosidesAnti-Bacterial AgentsClarithromycinDNA Mismatch RepairDrug Resistance, BacterialDrug Resistance, MicrobialHumansMacrolidesMicrobial Sensitivity TestsRNA, Ribosomal, 16SAminoglycosidesAnti-Bacterial AgentsClarithromycinMacrolidesRNA, Ribosomal, 16Sacquired resistanceaminoglycosidesantibiotic resistanceDNA repairdrug resistanceEndoMSmacrolidesmismatch repairmutationMycobacterium abscessusnoncanonical mismatch repairNucS

Identifiers

PMID36219122
PMCPMC9769700
OpenAlexW4304193824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.