ArticleClinical rheumatology1987
Serum concentration of vitamin D metabolites in rheumatoid arthritis.
Article in Clinical rheumatology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Drug-vitamin D interactions: a systematic review of the literature.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2013Pooled it
- Does vitamin D affect risk of developing autoimmune disease?: a systematic review.Seminars in arthritis and rheumatism · 2011Pooled it
- A Literature Review of the Potential Impact of Medication on Vitamin D Status.Risk management and healthcare policy · 2021Review
- Evolving Role of Vitamin D in Immune-Mediated Disease and Its Implications in Autoimmune Hepatitis.Digestive diseases and sciences · 2019Review
- Vitamin D as an Immunomodulator: Risks with Deficiencies and Benefits of Supplementation.Healthcare (Basel, Switzerland) · 2015Review
- Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis.BMC musculoskeletal disorders · 2014Article
- Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA.The Journal of rheumatology · 2009Article
- Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women.Annals of the rheumatic diseases · 2008Article
- Vitamin D3 metabolism in patients with rheumatic diseases: low serum levels of 25-hydroxyvitamin D3 in patients with systemic lupus erythematosus.Clinical rheumatology · 1995Article
- Osteopenia in rheumatoid arthritis: a biochemical, hormonal and histomorphometric study.Clinical rheumatology · 1990Article
- Assessment of Vitamin D in Rheumatoid Arthritis and Its Correlation with Disease Activity.Journal of natural science, biology, and medicineArticle
- Enrichment of vitamin D response elements in RA-associated loci supports a role for vitamin D in the pathogenesis of RA.Genes and immunityArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One-hundred and two patients with rheumatoid arthritis (RA) were studied. They were divided into three groups according to treatment with gold salts, penicillamine or glucocorticoids. Blood samples were drawn between November and January and four different metabolites of vitamin D (25(OH)D3, 24,25 (OH)2D3, 25,26 (OH)2D and 1,25 (OH)2D) were measured and compared to values from normal subjects. The mean serum concentrations of 25(OH)D3 in all three patient groups were significantly lower than those of the controls (p less than 0.01-0.001). The mean serum concentrations of 24,25 (OH)2D3 and 25,26 (OH)2D were not significantly different from the control values, whereas 1,25 (OH)2D concentrations were significantly lower in the penicillamine and steroid groups (p less than 0.05-0.01). When patients were stratified according to functional classes, we found a significant inverse relation between serum concentrations of 25(OH) D3, 24,25(OH)2D3, 25,26(OH)2D and the functional class, but not between 1,25(OH)2D and the functional class. We conclude that the decreased serum 25(OH)D3 concentration found in patients with RA is likely to be caused by decreased exposure to sunlight due to decreased activity, and thus is a result of the disease rather than a pathogenetic factor. Whether the small decrease in serum 1,25(OH)2D is of clinical significance and related to the development of osteoporosis in patients with RA is probably doubtful.
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Registered trials
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