Evidence map›Paper›PMID 36218376›Full record

ArticleThe Journal of clinical endocrinology and metabolism2023

Regional Variation in Hormonal and Metabolic Parameters of White and Black Women With PCOS in the United States.

Katherine VanHise, Jessica L Chan, Sahar Wertheimer, Roy G Handelsman, Ekaterina Clark, Rae Buttle, Erica T Wang, Ricardo Azziz, Margareta D Pisarska

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Katherine VanHiseCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0001-6353-2803
Jessica L ChanCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Sahar WertheimerCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Roy G HandelsmanCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0001-8418-0288
Ekaterina ClarkCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Rae ButtleCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Erica T WangCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Ricardo AzzizDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0002-3917-0483
Margareta D PisarskaCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0003-1096-6506
Cedars-Sinai Medical Center · USUniversity of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextOngoing research is needed to determine geo-epidemiologic differences of polycystic ovary syndrome (PCOS).

objectiveDetermine hormonal and metabolic parameters of women with PCOS in 2 environments.

methodsProspective cohort study.

settingTertiary-care based specialty clinics in Alabama and California. PATIENTS OR OTHER

participantsA total of 1610 women with PCOS by National Institutes of Health Criteria from 1987 to 2010.

interventionsInterview, physical examination, laboratory studies. MAIN OUTCOMES MEASURES: Demographic data, menstrual cycle history, and hormonal and metabolic parameters were collected. Hirsutism was defined as modified Ferriman-Gallwey scores ≥4. Androgen values greater than laboratory reference ranges or >95th percentile of all values were considered elevated (hyperandrogenemia). Metabolic parameters included body mass index (BMI), waist-hip-ratio (WHR), glucose tolerance test, and homeostatic model assessment for insulin resistance (HOMA-IR) scores.

resultsAlabama women with PCOS were younger with a higher BMI. After adjustment for age and BMI, Alabama women with PCOS were more likely hirsute (adjusted odds ratio [aOR], 1.8; 95% CI, 1.4-2.4; P < 0.001), with elevated HOMA-IR scores (adjusted beta coefficient 3.6; 95% CI, 1.61-5.5; P < 0.001). California women with PCOS were more likely to have hyperandrogenemia (free testosterone aOR, 0.14; 95% CI, 0.11-0.18; P < 0.001; total testosterone aOR, 0.41; 95% CI, 0.33-0.51). Results were similar when stratified by White race. In Black women with PCOS, BMI and WHR did not differ between locations, yet differences in androgen profiles and metabolic dysfunction remained.

conclusionAlabama women with PCOS, regardless of Black or White race, were more likely hirsute with metabolic dysfunction, whereas California women with PCOS were more likely to demonstrate hyperandrogenemia, highlighting potential environmental impacts on PCOS.

Indexed as

HyperandrogenismInsulin ResistancePolycystic Ovary SyndromeAndrogensBlack or African AmericanBody Mass IndexFemaleHirsutismHumansProspective StudiesTestosteroneUnited StatesWhiteAndrogensTestosteroneenvironmentepidemiologygeographyPCOSrace

Identifiers

PMID36218376
PMCPMC10210617
OpenAlexW4304481536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.