Evidence map›Paper›PMID 36218280›Full record

ArticleJournal of the American Society for Mass Spectrometry2022

Identification of Monomethyl Branched-Chain Lipids by a Combination of Liquid Chromatography Tandem Mass Spectrometry and Charge-Switching Chemistries.

Caitlin E Randolph, Connor H Beveridge, Sanjay Iyer, Stephen J Blanksby, Scott A McLuckey, Gaurav Chopra

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caitlin E RandolphDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, United States.
Connor H BeveridgeDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, United States.
Sanjay IyerDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, United States.
Stephen J BlanksbyCentral Analytical Research Facility and the School of Chemistry and Physics, Queensland University of Technology, Brisbane, QLD 4000, Australia.ORCID 0000-0002-8560-756X
Scott A McLuckeyDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, United States.ORCID 0000-0002-1648-5570
Gaurav ChopraDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, United States.ORCID 0000-0003-0942-7898

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Gas-phase Bio-conjugation in the Tandem Mass Spectrometry of Peptides, Proteins,R37GM045372 · NIGMS · PURDUE UNIVERSITY · PI MCLUCKEY, SCOTT A · 2014 to 2023
$3.1M
Mass spectrometry method with C=C location specificity for qualitative and quantitative lipid analysisR01GM118484 · NIGMS · PURDUE UNIVERSITY · PI MCLUCKEY, SCOTT A · 2016 to 2020
$1.6M
Development of a high throughput system for molecular imaging of different cell types in mouse brain tissuesRF1MH128866 · NIMH · PURDUE UNIVERSITY · PI CHOPRA, GAURAV, LASKIN, JULIA · 2021 to 2021
$1.5M
NCI NIH HHS P30 CA023168NIGMS NIH HHS R01 GM118484NIGMS NIH HHS R37 GM045372NIMH NIH HHS RF1 MH128866
6 · The paper itself

Abstract

While various mass spectrometric approaches have been applied to lipid analysis, unraveling the extensive structural diversity of lipids remains a significant challenge. Notably, these approaches often fail to differentiate between isomeric lipids─a challenge that is particularly acute for branched-chain fatty acids (FAs) that often share similar (or identical) mass spectra to their straight-chain isomers. Here, we utilize charge-switching strategies that combine ligated magnesium dications with deprotonated fatty acid anions. Subsequent activation of these charge inverted anions yields mass spectra that differentiate

Indexed as

Fatty AcidsTandem Mass SpectrometryChromatography, LiquidLipidsFatty AcidsLipids

Identifiers

PMID36218280
PMCPMC10173259

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.