Evidence map›Paper›PMID 36218234›Full record

ArticleeLife2022

Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation.

Mahlon A Collins, Gemechu Mekonnen, Frank Wolfgang Albert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mahlon A CollinsDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States.ORCID 0000-0001-6799-5645
Gemechu MekonnenDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States.
Frank Wolfgang AlbertDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States.ORCID 0000-0002-1380-8063
University of Minnesota · US

Funding

Genomic approaches for dissecting regulatory variationR35GM124676 · NIGMS · UNIVERSITY OF MINNESOTA · PI Frank Wolfgang Albert · 2017 to 2026
$4.6M
Genetic Influences on Protein Degradation in Large Yeast PopulationsF32GM128302 · NIGMS · UNIVERSITY OF MINNESOTA · PI COLLINS, MAHLON · 2019 to 2019
$63k
NIGMS NIH HHS F32 GM128302NIGMS NIH HHS R35 GM124676
6 · The paper itself

Abstract

Precise control of protein degradation is critical for life, yet how natural genetic variation affects this essential process is largely unknown. Here, we developed a statistically powerful mapping approach to characterize how genetic variation affects protein degradation by the ubiquitin-proteasome system (UPS). Using the yeast

Indexed as

Saccharomyces cerevisiae ProteinsUbiquitinAmino AcidsProteasome Endopeptidase ComplexProteolysisSaccharomyces cerevisiaeUbiquitin-Protein LigasesAmino AcidsProteasome Endopeptidase ComplexSaccharomyces cerevisiae ProteinsUbiquitinUbiquitin-Protein LigasesUBR1 protein, S cerevisiaecomplex traitgene expressiongeneticsgenetic variationgenomicsQTLS. cerevisiaeubiquitin system

Identifiers

PMID36218234
PMCPMC9634822
OpenAlexW4304190027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.