Evidence map›Paper›PMID 36218169›Full record

ReviewTransboundary and emerging diseases2022

The origins of COVID-19 pandemic: A brief overview.

Ying-Jian Hao, Yu-Lan Wang, Mei-Yue Wang, Lan Zhou, Jian-Yun Shi, Ji-Min Cao, De-Ping Wang

Open access · greenAbstract readReview
In one paragraph

Review in Transboundary and emerging diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 78 citations in OpenAlex.

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  6. Fingerprint-Based Machine Learning for SARS-CoV-2 and MERS-CoVJournal of chemical information and modeling · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ying-Jian HaoKey Laboratory of Cellular Physiology, Ministry of Education, Department of Physiology, Shanxi Medical University, Taiyuan, China.
Yu-Lan WangKey Laboratory of Cellular Physiology, Ministry of Education, Department of Physiology, Shanxi Medical University, Taiyuan, China.
Mei-Yue WangKey Laboratory of Cellular Physiology, Ministry of Education, Department of Physiology, Shanxi Medical University, Taiyuan, China.
Lan ZhouKey Laboratory of Cellular Physiology, Ministry of Education, Department of Physiology, Shanxi Medical University, Taiyuan, China.
Jian-Yun ShiKey Laboratory of Cellular Physiology, Ministry of Education, Department of Physiology, Shanxi Medical University, Taiyuan, China.
Ji-Min CaoKey Laboratory of Cellular Physiology, Ministry of Education, Department of Physiology, Shanxi Medical University, Taiyuan, China.ORCID https://orcid.org/0000-0002-6546-555X
De-Ping WangKey Laboratory of Cellular Physiology, Ministry of Education, Department of Physiology, Shanxi Medical University, Taiyuan, China.
Shanxi Medical University · CN

Funding

Applied Basic Research Program of Shanxi Province 201901D111189Applied Basic Research Program of Shanxi Province 201901D211316Doctor of Shanxi Medical University XD1809Key Medical Science and Technology Program of Shanxi Province 2020XM01National Natural Science Foundation of China 82002063National Natural Science Foundation of China 82170523Science Research Start-up Fund for Doctor of Shanxi Province SD1809Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi 2019L0414
6 · The paper itself

Abstract

The novel coronavirus disease (COVID-19) outbreak that emerged at the end of 2019 has now swept the world for more than 2 years, causing immeasurable damage to the lives and economies of the world. It has drawn so much attention to discovering how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated and entered the human body. The current argument revolves around two contradictory theories: a scenario of laboratory spillover events and human contact with zoonotic diseases. Here, we reviewed the transmission, pathogenesis, possible hosts, as well as the genome and protein structure of SARS-CoV-2, which play key roles in the COVID-19 pandemic. We believe the coronavirus was originally transmitted to human by animals rather than by a laboratory leak. However, there still needs more investigations to determine the source of the pandemic. Understanding how COVID-19 emerged is vital to developing global strategies for mitigating future outbreaks.

Indexed as

COVID-19SARS-CoV-2AnimalsDisease OutbreaksHumansPandemicsZoonosesgenome similaritieslaboratory originprotein structure evolutionSARS-CoV-2zoonotic origin

Identifiers

PMID36218169
PMCPMC9874793
OpenAlexW4304187487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.