Evidence map›Paper›PMID 36218068›Full record

ReviewThe Journal of physiology2023

The impact of Hodgkin-Huxley models on dendritic research.

Konstantinos-Evangelos Petousakis, Anthi A Apostolopoulou, Panayiota Poirazi

Abstract readReview
In one paragraph

Review in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. A cortical field theory - dynamics and symmetries.Journal of computational neuroscience · 2024
    Article
  8. Shaping dynamical neural computations using spatiotemporal constraints.Biochemical and biophysical research communications · 2024
    Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Konstantinos-Evangelos PetousakisInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece.ORCID 0000-0003-2022-1671
Anthi A ApostolopoulouInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece.ORCID 0000-0002-8174-4372
Panayiota PoiraziInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece.ORCID 0000-0001-6152-595X

Funding

Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representationsR01MH124867 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOSONCZY, ATTILA, POIRAZI, PANAYIOTA · 2021 to 2025
$3.4M
NIMH NIH HHS R01 MH124867
6 · The paper itself

Abstract

For the past seven decades, the Hodgkin-Huxley (HH) formalism has been an invaluable tool in the arsenal of neuroscientists, allowing for robust and reproducible modelling of ionic conductances and the electrophysiological phenomena they underlie. Despite its apparent age, its role as a cornerstone of computational neuroscience has not waned. The discovery of dendritic regenerative events mediated by ionic and synaptic conductances has solidified the importance of HH-based models further, yielding new predictions concerning dendritic integration, synaptic plasticity and neuronal computation. These predictions are often validated through in vivo and in vitro experiments, advancing our understanding of the neuron as a biological system and emphasizing the importance of HH-based detailed computational models as an instrument of dendritic research. In this article, we discuss recent studies in which the HH formalism is used to shed new light on dendritic function and its role in neuronal phenomena.

Indexed as

Models, NeurologicalNeuronsAction PotentialsElectrophysiological PhenomenaNeuronal Plasticityback-propagating action potentialsdendritic integrationdendritic modelsdendritic non-linearitiesHodgkin-Huxley-based modelsneuronal computationsynaptic plasticity

Identifiers

PMID36218068
PMCPMC10600871

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.