Evidence map›Paper›PMID 36218001›Full record

ReviewThe Journal of eukaryotic microbiology2022

The Toxoplasma plant-like vacuolar compartment (PLVAC).

Andrew J Stasic, Silvia N J Moreno, Vern B Carruthers, Zhicheng Dou

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of eukaryotic microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. bioRxiv : the preprint server for biology · 2026
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  12. AmSphere · 2024
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  18. A cathepsin C-like protease post-translationally modifiesbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Andrew J StasicDepartment of Microbiology, Heartland FPG, Carmel, Indiana, USA.ORCID 0000-0003-3209-6302
Silvia N J MorenoDepartment of Cellular Biology, University of Georgia, Georgia, Athens, USA.ORCID 0000-0002-2041-6295
Vern B CarruthersDepartment of Microbiology & Immunology, University of Michigan Medical School, Michigan, Ann Arbor, USA.ORCID 0000-0001-6859-8895
Zhicheng DouDepartment of Biological Sciences, Clemson University, South Carolina, Clemson, USA.ORCID 0000-0003-1887-1181
Clemson University · USUniversity of Georgia · USUniversity of Michigan · USUrology of Indiana · US

Funding

Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
Parasite autophagy as a key survival mechanism for the AIDS-associated pathogen Toxoplasma gondiiR01AI120607 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 2016 to 2025
$4.0M
The Toxoplasma apicoplast and calcium signalingR01AI128356 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2017 to 2021
$2.0M
Regulation of the physiology and function of the digestive vacuole in Toxoplasma gondiiR01AI143707 · NIAID · CLEMSON UNIVERSITY · PI DOU, ZHICHENG · 2020 to 2024
$1.8M
The plant-like vacuole of Toxoplasma gondiiR01AI096836 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2012 to 2016
$1.8M
Identifying novel players in Toxoplasma autophagy during chronic infection”R21AI160610 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 2021 to 2022
$429k
NIAID NIH HHS R01 AI096836NIAID NIH HHS R01 AI120607NIAID NIH HHS R01 AI128356NIAID NIH HHS R01 AI143707NIAID NIH HHS R21 AI160610NIAID NIH HHS T32 AI060546
6 · The paper itself

Abstract

Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of congenital disease and infection in immunocompromised patients. T. gondii shares several characteristics with plants including a nonphotosynthetic plastid termed apicoplast and a multivesicular organelle that was named the plant-like vacuole (PLV) or vacuolar compartment (VAC). The name plant-like vacuole was selected based on its resemblance in composition and function to plant vacuoles. The name VAC represents its general vacuolar characteristics. We will refer to the organelle as PLVAC in this review. New findings in recent years have revealed that the PLVAC represents the lysosomal compartment of T. gondii which has adapted peculiarities to fulfill specific Toxoplasma needs. In this review, we discuss the composition and functions of the PLVAC highlighting its roles in ion storage and homeostasis, endocytosis, exocytosis, and autophagy.

Indexed as

ApicoplastsToxoplasmaHumansPlantsProtozoan ProteinsVacuolesProtozoan Proteinsapicomplexancalciumdigestivelysosomeplant-like vacuoleToxoplasma gondiivacuolar compartmentzinc

Identifiers

PMID36218001
PMCPMC10576567
OpenAlexW4304184139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.