Evidence map›Paper›PMID 36217863›Full record

ArticleJournal of diabetes2022

Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study.

Yuanyue Zhu, Chunyan Hu, Lin Lin, Shuangyuan Wang, Hong Lin, Yanan Huo, Qin Wan, Yingfen Qin, Ruying Hu, Lixin Shi and 32 more

Abstract read
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Article in Journal of diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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3 citing papers in PubMed.

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5 · Who and what money

Authors and funding

42 authors.

Yuanyue Zhu *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-3114-3314
Chunyan Hu *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-8673-3859
Lin Lin *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuangyuan WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hong LinDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanan HuoJiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China.
Qin WanThe Affiliated Hospital of Luzhou Medical College, Luzhou, China.
Yingfen QinThe First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Ruying HuZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.ORCID https://orcid.org/0000-0002-5917-3454
Lixin ShiAffiliated Hospital of Guiyang Medical University, Guiyang, China.
Qing SuXinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xuefeng YuTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li YanSun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Guijun QinThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xulei TangThe First Hospital of Lanzhou University, Lanzhou, China.
Gang ChenFujian Provincial Hospital, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0002-8105-2384
Min XuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-3930-8718
Yu XuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tiange WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-0723-489X
Zhiyun ZhaoDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-5950-2732
Zhengnan GaoDalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China.
Guixia WangThe First Hospital of Jilin University, Changchun, China.
Feixia ShenThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zuojie LuoThe First Affiliated Hospital of Guangxi Medical University, Nanning, China.ORCID https://orcid.org/0000-0003-2969-8329
Li ChenQilu Hospital of Shandong University, Jinan, China.ORCID https://orcid.org/0000-0001-7670-8062
Qiang LiThe Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhen YeZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Yinfei ZhangCentral Hospital of Shanghai Jiading District, Shanghai, China.
Chao LiuJiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
Youmin WangThe First Affiliated Hospital of Anhui Medical University, Hefei, China.
Shengli WuKaramay Municipal People's Hospital, Xinjiang, China.
Tao YangThe First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Huacong DengThe First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Lulu ChenUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tianshu ZengUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jiajun ZhaoShandong Provincial Hospital affiliated to Shandong University, Jinan, China.
Yiming MuChinese People's Liberation Army General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-3344-3540
Weiqing WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guang NingDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yufang BiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuhong ChenDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-6506-2283
Jieli LuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-1317-0896

Funding

Clinical Research Plan of SHDC SHDC2020CR1001AClinical Research Plan of SHDC SHDC2020CR3064BClinical Research Project of Shanghai Municipal Health Commission 20214Y0002National Natural Science Foundation of China 21904084National Natural Science Foundation of China 81930021National Natural Science Foundation of China 81970691National Natural Science Foundation of China 81970728National Natural Science Foundation of China 82170819Science and Technology Committee of Shanghai 19411964200Science and Technology Committee of Shanghai 20Y11905100Shanghai Medical and Health Development Foundation DMRFP_I_01Shanghai Outstanding Academic Leaders Plan 20XD1422800
6 · The paper itself

Abstract

backgroundEvidence regarding the impact of education on diabetes risk is scarce in developing countries. We aimed to explore the association between education and diabetes within a large population in China and to identify the possible mediators between them.

methodsInformation on educational level and lifestyle factors was collected through questionnaires. Diabetes was diagnosed from self-report and biochemical measurements. A structural equation model was constructed to quantify the mediation effect of each mediator.

resultsCompared with their least educated counterparts, men with college education had a higher risk of diabetes (odds ratio [OR] 1.19; 95% confidence interval [CI], 1.12-1.27), while college-educated women were less likely to have diabetes (OR 0.77; 95% CI, 0.73-0.82). Obesity was the strongest mediator in both genders (proportion of mediation: 11.6% in men and 23.9% in women), and its association with education was positive in men (β[SE] 0.0387 [0.0037]) and negative in women (β[SE] -0.0824 [0.0030]). Taken together, all behavioral factors explained 12.4% of the excess risk of diabetes in men and 33.3% in women.

conclusionsIn a general Chinese population, the association between education level and diabetes was positive in men but negative in women. Obesity was the major mediator underlying the education disparities of diabetes risk, with a stronger mediation effect among women.

Indexed as

Diabetes MellitusObesityChinaEducational StatusFemaleHumansMaleRisk Factorsdiabeteseducationgender-dependentmediationobesity中介性别依赖教育糖尿病肥胖

Identifiers

PMID36217863
PMCPMC9705800

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