Evidence map›Paper›PMID 36217545›Full record

ArticleiScience2022

Lessons learned from pre-clinical testing of xenogeneic decellularized esophagi in a rabbit model.

Edward Hannon, Marco Pellegrini, Federico Scottoni, Natalie Durkin, Soichi Shibuya, Roberto Lutman, Toby J Proctor, J Ciaran Hutchinson, Owen J Arthurs, Demetra-Ellie Phylactopoulos and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Edward HannonGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Marco PellegriniGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Federico ScottoniGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Natalie DurkinGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Soichi ShibuyaGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Roberto LutmanGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Toby J ProctorCentre for Cell, Gene and Tissue Therapies, Royal Free Hospital & University College London, London NW3 2PF, UK.
J Ciaran HutchinsonGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Owen J ArthursGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Demetra-Ellie PhylactopoulosGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Elizabeth F MaughanGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Colin R ButlerGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Simon EatonGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Mark W LowdellCentre for Cell, Gene and Tissue Therapies, Royal Free Hospital & University College London, London NW3 2PF, UK.
Paola BonfantiGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Luca UrbaniThe Roger Williams Institute of Hepatology, Foundation for Liver Research, London SE5 9NT, UK.
Paolo De CoppiGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
University College London · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GBThe Francis Crick Institute · GBThe Royal Free Hospital · GBCharing Cross Hospital · GBKing's College London · GBLeeds Teaching Hospitals NHS Trust · GBOspedale Regina Margherita · IT

Funding

Medical Research Council MR/R002118/1
6 · The paper itself

Abstract

Decellularization of esophagi from several species for tissue engineering is well described, but successful implantation in animal models of esophageal replacement has been challenging. The purpose of this study was to assess feasibility and applicability of esophageal replacement using decellularized porcine esophageal scaffolds in a new pre-clinical model. Following surgical replacement in rabbits with a vascularizing muscle flap, we observed successful anastomoses of decellularized scaffolds, cues of early neovascularization, and prevention of luminal collapse by the use of biodegradable stents. However, despite the success of the surgical procedure, the long-term survival was limited by the fragility of the animal model. Our results indicate that transplantation of a decellularized porcine scaffold is possible and vascular flaps may be useful to provide a vascular supply, but long-term outcomes require further pre-clinical testing in a different large animal model.

Indexed as

Biological sciencesBiomedical engineeringBiotechnologyTissue engineering

Identifiers

PMID36217545
PMCPMC9547295
OpenAlexW4296628521

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.