Evidence map›Paper›PMID 36217412›Full record

ArticleOxidative medicine and cellular longevity2022

KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca

Ying-Chao Zhang, Feng-Ran Xiong, Cheng Cheng, Han Shen, Ru-Xuan Zhao, Juan-Juan Zhu, Lin Zhang, Jing Lu, Jin-Kui Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Changes of mCell biochemistry and biophysics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ying-Chao ZhangBeijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.ORCID https://orcid.org/0000-0002-1297-0763
Feng-Ran XiongBeijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.ORCID https://orcid.org/0000-0001-9309-0997
Cheng ChengBeijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.ORCID https://orcid.org/0000-0003-3406-1963
Han ShenBeijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.ORCID https://orcid.org/0000-0002-0900-6922
Ru-Xuan ZhaoBeijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.ORCID https://orcid.org/0000-0002-5236-1612
Juan-Juan ZhuBeijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.ORCID https://orcid.org/0000-0001-6987-4046
Lin ZhangBeijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.ORCID https://orcid.org/0000-0002-7137-5155
Jing LuBeijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.ORCID https://orcid.org/0000-0001-6744-7833
Jin-Kui YangBeijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.ORCID https://orcid.org/0000-0002-5430-2149
Beijing Tongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KCNH6 has been proven to affect glucose metabolism and insulin secretion both in humans and mice. Further study revealed that Kcnh6 knockout (KO) mice showed impaired glucose tolerance. However, the precise function of KCNH6 in the liver remains unknown. Mitochondria have been suggested to maintain intracellular Ca

Indexed as

Diabetes Mellitus, Type 2Ether-A-Go-Go Potassium ChannelsGlucoseMitochondriaOxidative StressAnimalsCalciumGlycogenHumansInsulinJNK Mitogen-Activated Protein KinasesLiverMiceMice, KnockoutNADPH OxidasesReactive Oxygen SpeciesCalciumEther-A-Go-Go Potassium ChannelsGlucoseGlycogenInsulinJNK Mitogen-Activated Protein KinasesKCNH6 protein, humanKcnh6 protein, mouseNADPH OxidasesReactive Oxygen SpeciesSuperoxides

Identifiers

PMID36217412
PMCPMC9547380
OpenAlexW4298091821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.