Evidence map›Paper›PMID 36217286›Full record

ArticleEcology2023

Experimental evidence that host species composition alters host-pathogen dynamics in a ranavirus-amphibian assemblage.

Paul W Snyder, Chloe T Ramsay, Carmen C Harjoe, Emily S Khazan, Cheryl J Briggs, Jason Todd Hoverman, Pieter T J Johnson, Daniel Preston, Jason R Rohr, Andrew R Blaustein

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Paul W SnyderIntegrative Biology, Oregon State University, Corvallis, Oregon, USA.ORCID 0000-0002-0444-2426
Chloe T RamsayDepartment of Integrative Biology, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-6909-272X
Carmen C HarjoeIntegrative Biology, Oregon State University, Corvallis, Oregon, USA.ORCID 0000-0001-6141-7270
Emily S KhazanSchool of Natural Resources and Environment, University of Florida, Gainesville, Florida, USA.
Cheryl J BriggsEcology, Evolution and Marine Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Jason Todd HovermanDepartment of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana, USA.
Pieter T J JohnsonDepartment of Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado, USA.
Daniel PrestonDepartment of Fish, Wildlife and Conservation Biology, Colorado State University, Fort Collins, Colorado, USA.ORCID 0000-0002-0486-3466
Jason R RohrDepartment of Integrative Biology, University of South Florida, Tampa, Florida, USA.ORCID 0000-0001-8285-4912
Andrew R BlausteinIntegrative Biology, Oregon State University, Corvallis, Oregon, USA.
Oregon State University · USUniversity of South Florida · USColorado State University · USPurdue University West Lafayette · USUniversity of California, Santa Barbara · USUniversity of Colorado Boulder · USUniversity of Florida · US

Funding

EID disease in complex communities: multi-host multi-pathogen interactionsR01GM109499 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI BRIGGS, CHERYL J · 2013 to 2016
$1.7M
From specialist to generalist: biotic and abiotic reservoirs of fungal pathogensR01GM135935 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI BRIGGS, CHERYL J · 2019 to 2022
$1.6M
NIGMS NIH HHS R01 GM109499NIGMS NIH HHS R01 GM135935
6 · The paper itself

Abstract

Losses in biodiversity can alter disease risk through changes in host species composition. Host species vary in pathogen susceptibility and competence, yet how changes in diversity alter host-pathogen dynamics remains unclear in many systems, particularly with respect to generalist pathogens. Amphibians are experiencing worldwide population declines linked to generalist pathogens, such as ranavirus, and thus represent an ideal group to investigate how host species composition affects disease risk. We conducted experiments in which amphibian larvae of three native species (Pacific tree frogs, Pseudacris regilla; Cascades frogs, Rana cascadae; and Western toads, Anaxyrus boreas) were exposed to ranavirus individually (in the laboratory) or as assemblages (in outdoor mesocosms). In a laboratory experiment, we observed low survival and high viral loads in P. regilla compared to the other species, suggesting that this species was highly susceptible to the pathogen. In the mesocosm experiment, we observed 41% A. boreas mortality when alone and 98% mortality when maintained with P. regilla and R. cascadae. Our results suggest that the presence of highly susceptible species can alter disease dynamics across multiple species, potentially increasing infection risk and mortality in co-occurring species.

Indexed as

RanavirusAmphibiansAnimalsAnuraHost SpecificityLarvaRanidaeamphibiansamplificationbiodiversityhost compositionranarvirussusceptibility

Identifiers

PMID36217286
PMCPMC9898091
OpenAlexW4304166130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.