ArticleBMC plant biology2022
Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development.
Article in BMC plant biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Research progress of omics technologies in forage breeding.Fundamental research · 2026Review
- Genome-wide association study (GWAS) and transcriptome analysis reveal new candidate genes for leaf size in alfalfa.BMC plant biology · 2026Article
- Global Transcriptome Analysis Reveals the Molecular Mechanism Underlying Seed Physical Dormancy Formation inGenes · 2025Article
- Single-Cell Omics in Legumes: Research Trends and Applications.Plants (Basel, Switzerland) · 2025Review
- Combining QTL mapping and RNA-Seq reveals candidate genes controlling flag leaf width in foxtail millet.BMC plant biology · 2025Article
- Molecular mechanisms underlying leaf enlargement in spaceflight-mutated 'Deqin'alfalfa.BMC genomics · 2025Article
- Different nontarget-site mechanisms underlie resistance to dicamba and 2,4-D in an Amaranthus tuberculatus population.Pest management science · 2025Article
- Genome-wide association study revealed candidate genes associated with leaf size in alfalfa (Medicago sativa L.).BMC plant biology · 2025Article
- Quantitative Trait Locus Mapping Combined with RNA Sequencing Identified Candidate Genes for Resistance to Powdery Mildew in Bitter Gourd (International journal of molecular sciences · 2024Article
- GWAS combined with QTL mapping reveals the genetic loci of leaf morphological characters in Nicotiana tabacum.BMC plant biology · 2024Article
- A genome-wide association study reveals novel loci and candidate genes associated with plant height variation in Medicago sativa.BMC plant biology · 2024Article
- Crop Landraces and Indigenous Varieties: A Valuable Source of Genes for Plant Breeding.Plants (Basel, Switzerland) · 2024Review
- Review on blueberry drought tolerance from the perspective of cultivar improvement.Frontiers in plant science · 2024Review
- Design principles for synthetic control systems to engineer plants.Plant cell reports · 2023Review
- Combining transcriptomics and metabolomics to identify key response genes for aluminum toxicity in the root system of Brassica napus L. seedlings.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Design, execution, and interpretation of plant RNA-seq analyses.Frontiers in plant science · 2023Review
- OMICS in Fodder Crops: Applications, Challenges, and Prospects.Current issues in molecular biology · 2022Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLeaf size affects crop canopy morphology and photosynthetic efficiency, which can influence forage yield and quality. It is of great significance to mine the key genes controlling leaf development for breeding new alfalfa varieties. In this study, we mapped leaf length (LL), leaf width (LW), and leaf area (LA) in an F1 mapping population derived from a cultivar named ZhongmuNo.1 with larger leaf area and a landrace named Cangzhou with smaller leaf area.
resultsThis study showed that the larger LW was more conducive to increasing LA. A total of 24 significant quantitative trait loci (QTL) associated with leaf size were identified on both the paternal and maternal linkage maps. Among them, nine QTL explained about 11.50-22.45% phenotypic variation. RNA-seq analysis identified 2,443 leaf-specific genes and 3,770 differentially expressed genes. Combining QTL mapping, RNA-seq alalysis, and qRT-PCR, we identified seven candidate genes associated with leaf development in five major QTL regions.
conclusionOur study will provide a theoretical basis for marker-assisted breeding and lay a foundation for further revealing molecular mechanism of leaf development in alfalfa.
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