Evidence map›Paper›PMID 36216980›Full record

ReviewVirchows Archiv : an international journal of pathology2023

New concepts in EBV-associated B, T, and NK cell lymphoproliferative disorders.

Leticia Quintanilla-Martinez, Steven H Swerdlow, Thomas Tousseyn, Carlos Barrionuevo, Shigeo Nakamura, Elaine S Jaffe

Open access · hybridAbstract readReview
In one paragraph

Review in Virchows Archiv : an international journal of pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 135 citations in OpenAlex.

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  13. Epstein-Barr Virus-Associated T/NK-Cell Neoplasms.Journal of medical virology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Leticia Quintanilla-MartinezInstitute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, University Hospital Tübingen, Eberhard-Karls-University, Tübingen, Germany. Leticia.quintanilla-fend@med.uni-tuebingen.de.ORCID http://orcid.org/0000-0001-7156-5365
Steven H SwerdlowDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Thomas TousseynDepartment of Pathology, UZ Leuven, University Hospitals, Leuven, Belgium.
Carlos BarrionuevoDepartment of Pathology, Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.
Shigeo NakamuraDepartment of Pathology, Nagoya University Hospital, Nagoya, Japan.
Elaine S JaffeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MA, USA.
Instituto Nacional de Enfermedades Neoplásicas · PENagoya University Hospital · JPNational Institutes of Health · USUniversitair Ziekenhuis Leuven · BEUniversity Children's Hospital Tübingen · DEUniversity of Pittsburgh · US

Funding

Lymphoma Disease Discovery and DefintionZIASC000550 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI JAFFE, ELAINE · 2009 to 2025
$16.9M
6 · The paper itself

Abstract

EBV-associated lymphoproliferative disorders (LPD) include conditions of B, T, and NK cell derivation with a wide clinicopathological spectrum ranging from indolent, self-limiting, and localized conditions to highly aggressive lymphomas. Since the 2016 World Health Organization (WHO) lymphoma classification, progress has been made in understanding the biology of the EBV-associated LPDs. The diagnostic criteria of EBV+ mucocutaneous ulcer and lymphomatoid granulomatosis have been refined, and a new category of EBV-positive polymorphic B cell LPD was introduced to encompass the full spectrum of EBV-driven B cell disorders. The differential diagnosis of these conditions is challenging. This report will present criteria to assist the pathologist in diagnosis. Within the group of EBV-associated T and NK cell lymphomas, a new provisional entity is recognized, namely, primary nodal EBV+ T or NK cell lymphoma. The EBV + T and NK cell LPDs in children have undergone major revisions. In contrast to the 2016 WHO classification, now four major distinct groups are recognized: hydroa vacciniforme (HV) LPD, severe mosquito bite allergy, chronic active EBV (CAEBV) disease, and systemic EBV-positive T cell lymphoma of childhood. Two forms of HV LPD are recognized: the classic and the systemic forms with different epidemiology, clinical presentation, and prognosis. The subclassification of PTLD, not all of which are EBV-positive, remains unaltered from the 2016 WHO classification. This review article summarizes the conclusions and the recommendations of the Clinical Advisory Committee (CAC), which are summarized in the International Consensus Classification of Mature Lymphoid Neoplasms.

Indexed as

Epstein-Barr Virus InfectionsLymphoma, T-CellLymphoproliferative DisordersChildHerpesvirus 4, HumanHumansKiller Cells, NaturalEBV+ LPD in childrenEBV+ lymphoproliferationsImmunosuppressionMucocutaneous ulcerPTLD

Identifiers

PMID36216980
PMCPMC9852222
OpenAlexW4304140119

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.