ArticleNature medicine2022
Association of step counts over time with the risk of chronic disease in the All of Us Research Program.
Article in Nature medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 139 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
139 citing papers in PubMed, 3 syntheses or guidelines pooled it, 199 citations in OpenAlex.
- Effectiveness of Physical Rehabilitation Interventions on Walking Capacity and Wearable Sensor-Derived Performance After Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Sensors (Basel, Switzerland) · 2026Pooled it
- Daily Step Count and Depression in Adults: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Association between physical activity and risk of gastroesophageal reflux disease: A systematic review and meta-analysis.Journal of sport and health science · 2024Pooled it
- Adherence to Accelerometer Use in Older Adults Undergoing mHealth Cardiac Rehabilitation: Secondary Analysis of a Randomized Clinical Trial.Journal of medical Internet research · 2025Trial
- Maintenance of Improvements in Walking Activity in Individuals with Chronic Stroke: Follow-Up From the PROWALKS Randomized Controlled Trial.Neurorehabilitation and neural repair · 2025Trial
- Human Telephone vs Text Message Counseling and Physical Activity Among Midlife and Older Adults: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Trial
- Research Study Attrition and Participant-Informed Retention Strategies Among Cancer Survivors.JAMA network open · 2026Article
- Advancing Neurorehabilitation and Recovery Through Human Movement Quantification via Wearable Sensing.Neurorehabilitation and neural repair · 2026Article
- Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables.Nature communications · 2026Article
- Prospective Physical Activity, Sitting and Sleep consortium (ProPASS): addressing methodological and geographical barriers to inform global public health guidelines, interventions and precision medicine.British journal of sports medicine · 2026Article
- Device and Data Access Considerations for Digital Health Studies Using Consumer-Grade Wearables: An Experience-Based Tutorial.Clinical and translational science · 2026Article
- Design and rationale of the my heart counts cardiovascular health study: a large-scale, fully digital biobank, and randomized trial of large language model-driven coaching of physical activity.American journal of preventive cardiology · 2026Article
- Association of genetic risk and physical activity with incident type 2 diabetes.The Journal of clinical endocrinology and metabolism · 2026Article
- Walkable neighborhoods are associated with lower psychological distress through device-measured physical activity: Evidence from the All of Us Research Program, United States.Preventive medicine · 2026Article
- Sustained Reduction in Cardiopulmonary Fitness in Long COVID: A Report from the RECOVER-adult Cohort Study.JACC. Advances · 2026Article
- Article
- Smartphone Step Data for Public Health: Insights From Surveillance in Japan and Future Perspectives.Journal of epidemiology · 2026Article
- Sensor wide association studies in digital medicine.NPJ digital medicine · 2026Review
- Feasibility of smartphone-based digital phenotyping to measure visual function and mental health outcomes in patients with inherited retinal diseases.NPJ digital medicine · 2026Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
The association between physical activity and human disease has not been examined using commercial devices linked to electronic health records. Using the electronic health records data from the All of Us Research Program, we show that step count volumes as captured by participants' own Fitbit devices were associated with risk of chronic disease across the entire human phenome. Of the 6,042 participants included in the study, 73% were female, 84% were white and 71% had a college degree, and participants had a median age of 56.7 (interquartile range 41.5-67.6) years and body mass index of 28.1 (24.3-32.9) kg m
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.