ArticleScientific reports2022
Contrast enhancement by location and volume is associated with long-term outcome after thrombectomy in acute ischemic stroke.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Prognostic significance of contrast staining following mechanical thrombectomy in acute ischaemic stroke.Stroke and vascular neurology · 2025Observational
- The Effectiveness of Deep Learning in the Differential Diagnosis of Hemorrhagic Transformation and Contrast Accumulation After Endovascular Thrombectomy in Acute Ischemic Stroke Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Clearance rate of contrast extravasation after endovascular therapy is associated with functional outcome and mediated by cerebral edema.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Quantitative contrast enhancement volume on immediate post-thrombectomy CT predicts symptomatic intracranial hemorrhage and functional outcomes in acute large vessel occlusion stroke.Frontiers in neurology · 2025Article
- Modified Alberta Stroke Program Early CT Score (ASPECTS) of Contrast Extravasation on Dual-Energy CT Predicts Haemorrhagic Transformation and Poor Outcome After Endovascular Thrombectomy.Therapeutics and clinical risk management · 2025Article
- Contrast Staining in Noninfarcted Tissue after Endovascular Treatment of Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2024Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Contrast enhancement (CE) on brain non-contrast computed tomography (NCCT) is common after endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS), but its association with clinical outcomes is not well established. The current study aimed to investigate this relationship. We retrospectively reviewed consecutive patients with acute ischemic stroke who had hyperdensity on NCCT immediately after EVT for anterior circulation large vessel occlusion (LVO) from January 2016 to December 2019. We used ASPECTS combined with volume measurement by 3D reconstruction to estimate the extent and location of CE. Multivariable regression analysis was conducted to explore the risk factors associated with clinical outcome. In this study, 113 of 158 (71.52%) anterior circulation AIS-LVO patients had hyperdensity on brain NCCT. After strict inclusion and exclusion criteria, a total of 64 patients were enrolled in the final analysis. In logistic regression analysis, CE-ASPECTS, CE volume, CE at the caudate nucleus, M4 and M6 region were associated with 3-month poor functional outcome after adjusting for confounding factors. The conventional variable model was used for reference, including age, initial NIHSS, the procedure time, stent retriever passes, recanalization status and baseline ASPECTS, with AUC of 0.73. When combined with the above-named variables (conventional variables + CE-ASPECTS + CE volume + CE at caudate nucleus + CE at M4 region + CE at M6 region), the predictive power was significantly improved, with AUC of 0.87 (95% CI 0.78-0.95). The spatial location and volume of CE on NCCT obtained immediately after EVT were independent and strong predictors for poor outcome at 3-months in patients with AIS after excluding definite hemorrhage by 24-h follow up CT.
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