Evidence map›Paper›PMID 36216799›Full record

ArticleNature communications2022

The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis.

Qi Zhang, Rober Abdo, Cristiana Iosef, Tomonori Kaneko, Matthew Cecchini, Victor K Han, Shawn Shun-Cheng Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed
23.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 164 citations in OpenAlex.

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84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qi Zhang *Department of Pathology and Laboratory Medicine, Western University, London, ON, N6A 5C1, Canada. qzhan33@uwo.ca.ORCID 0000-0003-4928-2742
Rober Abdo *Department of Pathology and Laboratory Medicine, Western University, London, ON, N6A 5C1, Canada.
Cristiana IosefDepartment of Biochemistry, Western University, London, ON, N6A 5C1, Canada.
Tomonori KanekoDepartment of Biochemistry, Western University, London, ON, N6A 5C1, Canada.ORCID 0000-0001-5448-9639
Matthew CecchiniDepartment of Pathology and Laboratory Medicine, Western University, London, ON, N6A 5C1, Canada.
Victor K HanChildren's Health Research Institute, 800 Commissioners Road East, London, ON, N6C 2V5, Canada.
Shawn Shun-Cheng LiDepartment of Biochemistry, Western University, London, ON, N6A 5C1, Canada. sli@uwo.ca.ORCID 0000-0003-3610-9035
Western University · CAChildren’s Health Research Institute · CA

Funding

CIHR MOP201809
6 · The paper itself

Abstract

Brain metastases (BrMs) are a common occurrence in lung cancer with a dismal outcome. To understand the mechanism of metastasis to inform prognosis and treatment, here we analyze primary and metastasized tumor specimens from 44 non-small cell lung cancer patients by spatial RNA sequencing, affording a whole transcriptome map of metastasis resolved with morphological markers for the tumor core, tumor immune microenvironment (TIME), and tumor brain microenvironment (TBME). Our data indicate that the tumor microenvironment (TME) in the brain, including the TIME and TBME, undergoes extensive remodeling to create an immunosuppressive and fibrogenic niche for the BrMs. Specifically, the brain TME is characterized with reduced antigen presentation and B/T cell function, increased neutrophils and M2-type macrophages, immature microglia, and reactive astrocytes. Differential gene expression and network analysis identify fibrosis and immune regulation as the major functional modules disrupted in both the lung and brain TME. Besides providing systems-level insights into the mechanism of lung cancer brain metastasis, our study uncovers potential prognostic biomarkers and suggests that therapeutic strategies should be tailored to the immune and fibrosis status of the BrMs.

Indexed as

Brain NeoplasmsCarcinoma, Non-Small-Cell LungLung NeoplasmsBiomarkers, TumorFibrosisHumansTranscriptomeTumor MicroenvironmentBiomarkers, Tumor

Identifiers

PMID36216799
PMCPMC9551067
OpenAlexW4304083982

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.