ArticleNature communications2022
Human papillomavirus integration perspective in small cell cervical carcinoma.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Multi-omics profiling reveals homologous recombination repair hyperactivation as a therapeutic vulnerability in neuroendocrine cervical carcinoma.Signal transduction and targeted therapy · 2026Article
- Basic Clinical Bidirectional Empowerment: Synergistic Breakthrough in Molecular Mechanisms and Clinical Management of Small Cell Cervical Carcinoma.International journal of molecular sciences · 2026Review
- A subset of high-grade sarcomas with myogenic differentiation are associated with recurrent FGFR fusions.The journal of pathology. Clinical research · 2026Article
- Molecular characterization of HPV integrations in high-risk HPV-positive women and development of a prognostic signature based on integration-associated genes for cervical cancer.Infectious agents and cancer · 2026Article
- ANKRD62 Modulates NF-κB Signaling to Promote Proliferation and Migration in UCEC.Cancer medicine · 2026Article
- HPV Integration in Head and Neck Cancer: Downstream Splicing Events and Expression Ratios Linked with Poor Outcomes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- From Viral Infection to Genome Reshaping: The Triggering Role of HPV Integration in Cervical Cancer.International journal of molecular sciences · 2025Review
- Human Papillomavirus Integration Induces Oncogenic Host Gene Fusions in Oropharyngeal Cancers.Cancer discovery · 2025Article
- Conundrum of 3N: nasopharyngeal nonkeratinizing non-viral carcinoma-reappraisal of fusions and report of two consecutive cases with unusual molecular findings.Virchows Archiv : an international journal of pathology · 2025Article
- Single-cell RNA sequencing reveals tumor heterogeneity in small cell neuroendocrine cervical carcinoma.Communications biology · 2025Article
- Advances in cervical cancer: current insights and future directions.Cancer communications (London, England) · 2025Review
- Article
- Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers.Molecular oncology · 2024Article
- FGFR1/2/3-rearranged carcinoma of the head and neck: expanded histological spectrum crossing path with high-risk HPV in the sinonasal tract.Histopathology · 2024Article
- Decoding the basis of histological variation in human cancer.Nature reviews. Cancer · 2024Review
- Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/β-catenin signaling activation.Cell death & disease · 2023Article
- BRD4 as a potential target for human papillomaviruses associated cancer.Journal of medical virology · 2023Review
- Human papillomavirus associated cervical lesion: pathogenesis and therapeutic interventions.MedComm · 2023Review
- Clinical characterization and genomic landscape of gynecological cancers among patients attending a Chinese hospital.Frontiers in oncology · 2023Article
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Authors and funding
45 authors.
Xiaoli Wang *Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.ORCID 0000-0002-0264-5131
Wenlong Jia *City University of Hong Kong Shenzhen Research Institute, Shenzhen, P. R. China.ORCID 0000-0002-7136-9919
Mengyao Wang *City University of Hong Kong Shenzhen Research Institute, Shenzhen, P. R. China.ORCID 0000-0002-2681-3873
Jihong Liu *Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.
Xianrong Zhou *Obstetrics and Gynecology Hospital of Fudan University, Shanghai, P. R. China.
Zhiqing Liang *Department of Gynecologic Oncology, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China.
Qinghua ZhangDepartment of Gynecology & Obstetrics, The Central Hospital of Wuhan, Wuhan, P. R. China.
Sixiang LongDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Suolang QuzhenDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Xiangchun LiTianjin Cancer Institute, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P. R. China.ORCID 0000-0002-2230-2152
Qiang TianNational Infrastructures of Translational Medicine (Shanghai), Shanghai JiaoTong University School of Medicine, Shanghai, P. R. China.
Xiong LiDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Haiying SunDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Caili ZhaoDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Silu MengDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Ruoqi NingDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Ling XiDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Lin WangDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Shasha ZhouDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Jianwei ZhangDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.ORCID 0000-0002-5788-2767
Li WuDepartment of Gynecologic Oncology, Hunan ProvinceTumor Hospital, Changsha, P. R. China.
Yile ChenDepartment of Gynecologic Oncology, Hunan ProvinceTumor Hospital, Changsha, P. R. China.
Aijun LiuDepartment of Pathology, Chinese People's Liberation Army General Hospital, Beijing, P. R. China.
Yaqi MaDepartment of Pathology, Chinese People's Liberation Army General Hospital, Beijing, P. R. China.
Xia ZhaoDepartment of Gynecologic Oncology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.
Xiaodong ChengWomen's Reproductive Health Laboratory of Zhejiang Province, Zhejiang, P. R. China.
Qing ZhangDepartment of Gynecology & Obstetrics, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
Xiaobing HanDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, P. R. China.
Huaxiong PanUnionHospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Yuan ZhangUnionHospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Lili CaoDepartment of Gynecology & Obstetrics, The Central Hospital of Wuhan, Wuhan, P. R. China.
Yiqin WangDepartment of Gynecologic Oncology, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China.
Shaoping LingGenome Wisdom Inc., Beijing, P. R. China.ORCID 0000-0002-6437-3645
Lihua CaoGenome Wisdom Inc., Beijing, P. R. China.
Hui XingDepartment of Obstetrics and Gynecology, Xiangfan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Xiangfan, Hubei, P. R. China.
Chang XuCity University of Hong Kong Shenzhen Research Institute, Shenzhen, P. R. China.ORCID 0000-0003-0589-9580
Long SuiObstetrics and Gynecology Hospital of Fudan University, Shanghai, P. R. China.
Shixuan WangDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Jianfeng ZhouCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.ORCID 0000-0002-1332-9230
Beihua KongDepartment of Gynecology & Obstetrics, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
Xing XieWomen's Reproductive Health Laboratory of Zhejiang Province, Zhejiang, P. R. China.
Gang ChenDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China. tjchengang@hust.edu.cn.ORCID 0000-0002-8320-6594
Shuaicheng LiCity University of Hong Kong Shenzhen Research Institute, Shenzhen, P. R. China. shuaicli@cityu.edu.hk.ORCID 0000-0001-6246-6349
Ding MaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China. dma@tjh.tjmu.edu.cn.ORCID 0000-0003-3317-7016
Shuang LiDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China. lee5190008@126.com.ORCID 0000-0002-9193-0320
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small cell cervical carcinoma (SCCC) is a rare but aggressive malignancy. Here, we report human papillomavirus features and genomic landscape in SCCC via high-throughput HPV captured sequencing, whole-genome sequencing, whole-transcriptome sequencing, and OncoScan microarrays. HPV18 infections and integrations are commonly detected. Besides MYC family genes (37.9%), we identify SOX (8.4%), NR4A (6.3%), ANKRD (7.4%), and CEA (3.2%) family genes as HPV-integrated hotspots. We construct the genomic local haplotype around HPV-integrated sites, and find tandem duplications and amplified HPV long control regions (LCR). We propose three prominent HPV integration patterns: duplicating oncogenes (MYCN, MYC, and NR4A2), forming fusions (FGFR3-TACC3 and ANKRD12-NDUFV2), and activating genes (MYC) via the cis-regulations of viral LCRs. Moreover, focal CNA amplification peaks harbor canonical cancer genes including the HPV-integrated hotspots within MYC family, SOX2, and others. Our findings may provide potential molecular criteria for the accurate diagnosis and efficacious therapies for this lethal disease.
Indexed as
AlphapapillomavirusCarcinoma, Small CellPapillomavirus InfectionsUterine Cervical NeoplasmsFemaleHumansMicrotubule-Associated ProteinsN-Myc Proto-Oncogene ProteinNuclear ProteinsPapillomaviridaeVirus IntegrationANKRD12 protein, humanMicrotubule-Associated ProteinsN-Myc Proto-Oncogene ProteinNuclear ProteinsTACC3 protein, human
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