Evidence map›Paper›PMID 36216432›Full record

ArticleBMJ open2022

Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol.

Alexis F Turgeon, Dean A Fergusson, Lucy Clayton, Marie-Pier Patton, Ryan Zarychanski, Shane English, Annemarie Docherty, Timothy Walsh, Donald Griesdale, Andreas H Kramer and 20 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03260478 (HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN), which is not on this map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03260478 nacompletednot on this map

HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial

TypeinterventionalSponsorCHU de Quebec-Universite LavalRan2017 to 2024Enrolled742ConditionsTraumatic Brain Injury, TransfusionArmsRed Blood Cells Transfusion
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Observational
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Alexis F TurgeonPopulation Health and Optimal Practices Research Unit (Trauma- Emergency-Critical Care Medicine), CHU de Québec-Universite Laval Research Center, Québec City, Québec, Canada alexis.turgeon@fmed.ulaval.ca.ORCID 0000-0001-5675-8791
Dean A FergussonClinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.ORCID 0000-0002-3389-2485
Lucy ClaytonPopulation Health and Optimal Practices Research Unit (Trauma- Emergency-Critical Care Medicine), CHU de Québec-Universite Laval Research Center, Québec City, Québec, Canada.
Marie-Pier PattonPopulation Health and Optimal Practices Research Unit (Trauma- Emergency-Critical Care Medicine), CHU de Québec-Universite Laval Research Center, Québec City, Québec, Canada.
Ryan ZarychanskiDepartment of Internal Medicine, Section of Hematology/Oncology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Shane EnglishClinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Annemarie DochertyCentre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh, UK.
Timothy WalshCentre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh, UK.
Donald GriesdaleDepartment of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
Andreas H KramerDepartment of Critical Care Medicine, Foothills Medical Center, University of Calgary, Calgary, Alberta, Canada.
Damon ScalesInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
Karen E A BurnsInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
John Gordon BoydDepartment of Medicine, Division of Neurology, Queen's University, Kingston, Ontario, Canada.
John C MarshallInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
Demetrios J KutsogiannisDepartment of Critical Care Medicine, University of Alberta, Edmonton, Alberta, Canada.
Ian BallDepartment of Medicine, Western University, London, Ontario, Canada.
Paul C HébertDepartment of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Francois LamontagneDepartment of Medicine, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Olivier CosteroussePopulation Health and Optimal Practices Research Unit (Trauma- Emergency-Critical Care Medicine), CHU de Québec-Universite Laval Research Center, Québec City, Québec, Canada.
Maude St-OngePopulation Health and Optimal Practices Research Unit (Trauma- Emergency-Critical Care Medicine), CHU de Québec-Universite Laval Research Center, Québec City, Québec, Canada.
Paule Lessard BonaventurePopulation Health and Optimal Practices Research Unit (Trauma- Emergency-Critical Care Medicine), CHU de Québec-Universite Laval Research Center, Québec City, Québec, Canada.
Lynne MoorePopulation Health and Optimal Practices Research Unit (Trauma- Emergency-Critical Care Medicine), CHU de Québec-Universite Laval Research Center, Québec City, Québec, Canada.
Xavier NeveuPopulation Health and Optimal Practices Research Unit (Trauma- Emergency-Critical Care Medicine), CHU de Québec-Universite Laval Research Center, Québec City, Québec, Canada.
Andrea RigamontiInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
Kosar KhwajaDepartment of Critical Care Medicine, McGill University, Montréal, Québec, Canada.
Robert S GreenDepartments of Emergency Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Vincent LarochePopulation Health and Optimal Practices Research Unit (Trauma- Emergency-Critical Care Medicine), CHU de Québec-Universite Laval Research Center, Québec City, Québec, Canada.
Alison Fox-RobichaudDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-9912-3606
Francois LauzierPopulation Health and Optimal Practices Research Unit (Trauma- Emergency-Critical Care Medicine), CHU de Québec-Universite Laval Research Center, Québec City, Québec, Canada.ORCID 0000-0002-6530-5513
HEMOTION Trial Team, the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group and the Canadian Traumatic Brain Injury Research Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTraumatic brain injury (TBI) is the leading cause of mortality and long-term disability in young adults. Despite the high prevalence of anaemia and red blood cell transfusion in patients with TBI, the optimal haemoglobin (Hb) transfusion threshold is unknown. We undertook a randomised trial to evaluate whether a liberal transfusion strategy improves clinical outcomes compared with a restrictive strategy. METHODS AND ANALYSIS: ETHICS AND DISSEMINATION: This trial is approved by the CHU de Québec-Université Laval research ethics board (MP-20-2018-3706) and ethic boards at all participating sites. Our results will be published and shared with relevant organisations and healthcare professionals. TRIAL REGISTRATION NUMBER: NCT03260478.

Indexed as

Brain Injuries, TraumaticQuality of LifeBlood TransfusionErythrocyte TransfusionHemoglobinsHumansMulticenter Studies as TopicPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicHemoglobinsAdult intensive & critical careINTENSIVE & CRITICAL CARENeurological injuryTRAUMA MANAGEMENT

Identifiers

PMID36216432
PMCPMC9557781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.