Evidence map›Paper›PMID 36215733›Full record

ArticleBiochemistry2023

Tryptophan Can Promote Oxygen Reduction to Water in a Biosynthetic Model of Heme Copper Oxidases.

Aaron P Ledray, Sudharsan Dwaraknath, Khetpakorn Chakarawet, Madeline R Sponholtz, Claire Merchen, Casey Van Stappen, Guodong Rao, R David Britt, Yi Lu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. A Bioinspired Nonheme FeJournal of the American Chemical Society · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Aaron P LedrayDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-1829-1235
Sudharsan DwaraknathDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Khetpakorn ChakarawetDepartment of Chemistry, University of California, Davis, California 95616, United States.ORCID 0000-0001-5905-3578
Madeline R SponholtzDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0002-0671-670X
Claire MerchenDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Casey Van StappenDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-1770-2231
Guodong RaoDepartment of Chemistry, University of California, Davis, California 95616, United States.ORCID 0000-0001-8043-3436
R David BrittDepartment of Chemistry, University of California, Davis, California 95616, United States.ORCID 0000-0003-0889-8436
Yi LuDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0003-1221-6709
University of Illinois Urbana-Champaign · USUniversity of California, Davis · USThe University of Texas at Austin · US

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Supplement:Spectroscopy Investigations of Metalloenzyme MechanismsR35GM126961 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI R. David Britt · 2018 to 2026
$3.7M
Design and Selection of Novel Metalloenzymes for Biocatalysis, Bioimaging, and Genetic EngineeringR35GM141931 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Yi Lu · 2021 to 2026
$3.5M
NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R35 GM126961NIGMS NIH HHS R35 GM141931
6 · The paper itself

Abstract

Heme-copper oxidases (HCOs) utilize tyrosine (Tyr) to donate one of the four electrons required for the reduction of O

Indexed as

HemeTryptophanHydrogen PeroxideOxidation-ReductionOxidoreductasesOxygenTyrosineWaterHemeHydrogen PeroxideOxidoreductasesOxygenTryptophanTyrosineWater

Identifiers

PMID36215733
PMCPMC10199329
OpenAlexW4304112883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.