ArticleProceedings of the National Academy of Sciences of the United States of America2022
Language and developmental plasticity after perinatal stroke.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 71 citations in OpenAlex.
- The cerebellum specializes for language even in the absence of contralateral neocortical inputs.bioRxiv : the preprint server for biology · 2026Article
- Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026Article
- An innovative treatment for hypoxic-ischemic encephalopathy: Silk fibroin nanomaterials improve neural stem cell axon formation and facilitate cognitive improvement.Neural regeneration research · 2026Article
- Faces and Word Forms Can Coexist in the Right Ventro-occipital Temporal Cortex-Evidence from Left-Hemisphere Perinatal Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Precision fMRI reveals that the language network exhibits adult-like left-hemispheric lateralization by 4 years of age.Nature communications · 2026Article
- Brain network characteristics and behavioral correlations in global developmental delay based on functional near-infrared spectroscopy.iScience · 2026Article
- Right hemisphere language network plasticity in aphasia.Brain : a journal of neurology · 2026Article
- Brain morphometry and cognition in late-onset glutaric aciduria type 1: scoping review and novel insights from a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- The emergence of the language system in the toddler brain.bioRxiv : the preprint server for biology · 2026Article
- Dense Phenotyping of Human Brain Network Organization Using Precision fMRI.Annual review of psychology · 2026Review
- Identifying left and right hemispheres using functional connectivity.bioRxiv : the preprint server for biology · 2025Article
- Lesion-Symptom Mapping of Acute Speech Deficits After Left vs. Right Hemisphere Stroke: A Retrospective Analysis of NIHSS Best Language Scores and Clinical Neuroimaging.Brain sciences · 2025Article
- Long-Term Cognitive and Language Outcomes at the Age of Seven Following Arterial Presumed Perinatal Ischemic Stroke: A Case Report.Brain sciences · 2025Article
- Functional connectivity between non-motor and motor networks predicts motor recovery changes after stroke.Scientific reports · 2025Article
- Precision fMRI reveals that the language network exhibits adult-like left-hemispheric lateralization by 4 years of age.bioRxiv : the preprint server for biology · 2025Article
- Language Functional Connectivity Alterations During Resting State in Brain Arteriovenous Malformation Patients.CNS neuroscience & therapeutics · 2025Article
- Functional Connectivity of Hippocampal Circuits and Visual Memory Function in Children and Adolescents With Perinatal Stroke.Human brain mapping · 2025Article
- Morphometrics of the preserved post-surgical hemisphere in pediatric drug-resistant epilepsy and implications for post-operative cognition.bioRxiv : the preprint server for biology · 2025Article
- Cross-sectional and longitudinal changes in category selectivity in visual cortex following pediatric cortical resection.Communications biology · 2025Article
- Assessing the Early Lateralization of White Matter in the Infant Language Network.Human brain mapping · 2025Article
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Authors and funding
13 authors at 3 institutions in 1 country.
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Abstract
The mature human brain is lateralized for language, with the left hemisphere (LH) primarily responsible for sentence processing and the right hemisphere (RH) primarily responsible for processing suprasegmental aspects of language such as vocal emotion. However, it has long been hypothesized that in early life there is plasticity for language, allowing young children to acquire language in other cortical regions when LH areas are damaged. If true, what are the constraints on functional reorganization? Which areas of the brain can acquire language, and what happens to the functions these regions ordinarily perform? We address these questions by examining long-term outcomes in adolescents and young adults who, as infants, had a perinatal arterial ischemic stroke to the LH areas ordinarily subserving sentence processing. We compared them with their healthy age-matched siblings. All participants were tested on a battery of behavioral and functional imaging tasks. While stroke participants were impaired in some nonlinguistic cognitive abilities, their processing of sentences and of vocal emotion was normal and equal to that of their healthy siblings. In almost all, these abilities have both developed in the healthy RH. Our results provide insights into the remarkable ability of the young brain to reorganize language. Reorganization is highly constrained, with sentence processing almost always in the RH frontotemporal regions homotopic to their location in the healthy brain. This activation is somewhat segregated from RH emotion processing, suggesting that the two functions perform best when each has its own neural territory.
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