Evidence map›Paper›PMID 36215464›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Microbiome composition modulates secondary metabolism in a multispecies bacterial community.

Marc G Chevrette, Chris S Thomas, Amanda Hurley, Natalia Rosario-Meléndez, Kris Sankaran, Yixing Tu, Austin Hall, Shruthi Magesh, Jo Handelsman

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
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  3. Enhanced Endophytic Colonization of Flavobacterium Promotes Plant Resistance to Fusarium Wilt.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  11. Confrontations betweenApplied and environmental microbiology · 2026
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marc G ChevretteWisconsin Institute for Discovery, Madison, WI 53715.ORCID 0000-0002-7209-0717
Chris S ThomasWisconsin Institute for Discovery, Madison, WI 53715.ORCID 0000-0002-4541-1634
Amanda HurleyWisconsin Institute for Discovery, Madison, WI 53715.ORCID 0000-0002-8322-4143
Natalia Rosario-MeléndezWisconsin Institute for Discovery, Madison, WI 53715.ORCID 0000-0003-1665-4167
Kris SankaranWisconsin Institute for Discovery, Madison, WI 53715.ORCID 0000-0002-9415-1971
Yixing TuDepartment of Statistics, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-4887-495X
Austin HallWisconsin Institute for Discovery, Madison, WI 53715.ORCID 0000-0002-2476-2750
Shruthi MageshWisconsin Institute for Discovery, Madison, WI 53715.
Jo HandelsmanWisconsin Institute for Discovery, Madison, WI 53715.
University of Wisconsin–Madison · USWisconsin Institutes for Discovery · US

Funding

Biotechnology Training ProgramT32GM135066 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCOTT M. COYLE, BRIAN G FOX · 2020 to 2026
$7.0M
Acquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1M
NCRR NIH HHS S10 RR029531NIGMS NIH HHS T32 GM135066
6 · The paper itself

Abstract

Bacterial secondary metabolites are a major source of antibiotics and other bioactive compounds. In microbial communities, these molecules can mediate interspecies interactions and responses to environmental change. Despite the importance of secondary metabolites in human health and microbial ecology, little is known about their roles and regulation in the context of multispecies communities. In a simplified model of the rhizosphere composed of

Indexed as

MicrobiotaSiderophoresAnti-Bacterial AgentsBenzamidesHumansSecondary MetabolismAnti-Bacterial AgentsBenzamidespetrobactinSiderophorescommunity interactionsmetametabolomicsmetatranscriptomicsmicrobiomesecondary metabolism

Identifiers

PMID36215464
PMCPMC9586298
OpenAlexW4304098556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.