ArticleJournal of the Optical Society of America. A, Optics, image science, and vision2022
Estimating optical parameters of biological tissues with photon-counting micro-CT.
Article in Journal of the Optical Society of America. A, Optics, image science, and vision, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Wavelength-dependent absorption and scattering properties determine the fluorescence photon transport in biological tissues and image resolution of optical molecular tomography. Currently, these parameters are computed from optically measured data. For small animal imaging, estimation of optical parameters is a large-scale optimization problem, which is highly ill-posed. In this paper, we propose a new, to the best of our knowledge, approach to estimate optical parameters of biological tissues with photon-counting micro-computed tomography (micro-CT). From photon-counting x-ray data, multi-energy micro-CT images can be reconstructed to perform multi-organ segmentation and material decomposition in terms of tissue constituents. The concentration and characteristics of major tissue constituents can be utilized to calculate the optical absorption and scattering coefficients of the involved tissues. In our study, we perform numerical simulation, phantom experiments, and in vivo animal studies to calculate the optical parameters using our proposed approach. The results show that our approach can estimate optical parameters of tissues with a relative error of <10
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