Observational studyPLoS neglected tropical diseases2022
Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh.
Observational study in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Epidemiological Characteristics of Dengue Infection in Bangladesh: A Systematic Review.International journal of environmental research and public health · 2026Pooled it
- Evolving epidemiology, clinical features, and genotyping of dengue outbreaks in Bangladesh, 2000-2024: a systematic review.Frontiers in microbiology · 2024Pooled it
- Severe Dengue in Children: Pathogenesis, Early Recognition, and Evidence-Informed Management.Tropical medicine and infectious disease · 2026Review
- Article
- Health-related quality of life and associated factors among hospitalized dengue patients in Bangladesh: a cross-sectional study.BMC infectious diseases · 2026Observational
- Factors Associated With Severe Dengue During the 2019 Outbreak in Southern Colombia: Implications for Hyperendemic Regions.Journal of tropical medicine · 2026Article
- Pediatric Health, Climate Perceptions, and School Absenteeism Across Three Regions of Bangladesh: A Cross-Sectional Study.International journal of environmental research and public health · 2025Article
- Risk factors predicting dengue hospitalization and disease severity in children and adolescents living in an endemic area of arbovirus transmission in Northeast Brazil (2017-2020).BMC public health · 2025Article
- Increase of Dengue in Pediatric Travelers in Madrid: A Multicentric Retrospective Experience.Tropical medicine and infectious disease · 2025Article
- Clinical and Laboratory Features and Treatment Outcomes of Dengue Fever in Pediatric Cases.Cureus · 2024Article
- The 2023 Dengue Outbreak in Bangladesh: Exploring the Epidemiology in Hospitalized Patients.The American journal of tropical medicine and hygiene · 2024Observational
- Clinical Manifestations of Dengue in Children and Adults in a Hyperendemic Region of Colombia.The American journal of tropical medicine and hygiene · 2024Article
- Predictive Value of Mean Platelet Volume and Other CBC Indices for Thrombocytopenia in Pediatric Dengue Fever: A Prospective Observational Study.Sage open pediatricsArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical and hematological parameters of children with dengue during an outbreak in a non-endemic region have not been well described. To delineate the clinical profile of pediatric cases from a tertiary care center located in a non-endemic zone (Tangail district) in Bangladesh was the objective of the study.
methodsA cross-sectional observational study was conducted in the Department of Pediatrics of a 250-bed general hospital in Tangail, Bangladesh, between June 2019 to September 2019. Data collection was done using a pre-structured case record form. All patients underwent detailed history taking, physical examination, and hematological profiling. A total of 123 confirmed dengue cases were analyzed.
resultsThe average age of patients was 7.3±4.1 (SD) years, with nearly two-thirds being male (61.8%) and the majority living in rural areas (76.4%). Fever (100%), body ache (57.7%), headache (56.9%), and rash (55.3%) were the four common clinical manifestations. NS1 antigen and anti-dengue IgM antibody tests were positive in 86% (102 out of 119) and 37.7% (20 out of 53) of cases, respectively. Thrombocytopenia was present in 42% of cases. The majority of the cases had dengue fever (73.2%), and the remaining cases were either dengue hemorrhagic fever or dengue shock syndrome (26.8%). Clinical and hematological parameters varied with the type of dengue. Particularly, rash (p = <0.001), bleeding manifestation (p = <0.001), vomiting (p = 0.012), hypotension (p = 0.018), pleural effusion (p = 0.018), ascites (p = 0.018), hepatomegaly (p = <0.001) and low platelet count (<150 x 103cells/μL) (p = 0.038) were significantly more common among dengue hemorrhagic fever or dengue shock syndrome cases.
conclusionsThe present study documented the clinical features of dengue in a pediatric group of patients from a non-endemic zone of Bangladesh. This vulnerable patient group requires earlier identification and keen attention during management.
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