Evidence map›Paper›PMID 36215322›Full record

ArticlePLoS computational biology2022

Chaos in synthetic microbial communities.

Behzad D Karkaria, Angelika Manhart, Alex J H Fedorec, Chris P Barnes

Abstract read
In one paragraph

Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Chaos in a bacterial stress response.Current biology : CB · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Behzad D KarkariaDepartment of Cell & Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0003-2627-9794
Angelika ManhartDepartment of Mathematics, University College London, London, United Kingdom.ORCID 0000-0002-0303-8114
Alex J H FedorecDepartment of Cell & Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0003-0165-1705
Chris P BarnesDepartment of Cell & Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0002-9459-1395

Funding

Biotechnology and Biological Sciences Research Council 1758911Wellcome Trust 209409/Z/17/Z
6 · The paper itself

Abstract

Predictability is a fundamental requirement in biological engineering. As we move to building coordinated multicellular systems, the potential for such systems to display chaotic behaviour becomes a concern. Therefore understanding which systems show chaos is an important design consideration. We developed a methodology to explore the potential for chaotic dynamics in small microbial communities governed by resource competition, intercellular communication and competitive bacteriocin interactions. Our model selection pipeline uses Approximate Bayesian Computation to first identify oscillatory behaviours as a route to finding chaotic behaviour. We have shown that we can expect to find chaotic states in relatively small synthetic microbial systems, understand the governing dynamics and provide insights into how to control such systems. This work is the first to query the existence of chaotic behaviour in synthetic microbial communities and has important ramifications for the fields of biotechnology, bioprocessing and synthetic biology.

Indexed as

BacteriocinsMicrobiotaBayes TheoremMicrobial ConsortiaSynthetic BiologyBacteriocins

Identifiers

PMID36215322
PMCPMC9584520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.