Trial reportAmerican journal of respiratory and critical care medicine2023
Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III).
Abstract readRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
6.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Efficacy and Safety of Dexmedetomidine-Esketamine Versus Dexmedetomidine Alone as Premedication for Pediatric Anesthesia Induction: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.Paediatric anaesthesia · 2026Pooled it
- Efficacy and safety of midazolam versus dexmedetomidine in mechanically ventilated intensive care unit patients: a systematic review and meta-analysis.Frontiers in pharmacology · 2026Pooled it
- A systematic meta-review of interventions to prevent and manage delirium in the Intensive Care Unit: Part 1 - Pharmacological interventions.Critical care (London, England) · 2025Pooled it
- Effect of dexmedetomidine on postoperative mortality and prognosis: a systematic review and meta-analysis of randomized controlled trials.BMC anesthesiology · 2025Pooled it
- Alpha2 agonists for sedation to produce better outcomes for adults with critical illness: a synopsis of the A2B RCT with cost-effectiveness and process evaluation.Health technology assessment (Winchester, England) · 2026Trial
- Comparing the efficacy of fospropofol with propofol and midazolam for goal-directed sedation in critically ill patients: a prospective, open-label, pilot, randomized controlled trial.BMC anesthesiology · 2026Trial
- Effects of Esketamine Combined with Dexmedetomidine on Early Postoperative Cognitive Function in Elderly Patients Undergoing Lumbar Spinal Surgery: A Double-Blind Randomized Controlled Clinical Trial.Drug design, development and therapy · 2024Trial
- A circuit dissection of perception-action decoupling in S-ketamine-induced hallucination-like states.Molecular psychiatry · 2026Article
- Critical care delirium: prevention, identification and management: a narrative review.Anaesthesia · 2026Review
- Olanzapine versus low-dose dexmedetomidine for delirium in patients with critical illness: a randomized clinical trial.American journal of respiratory and critical care medicine · 2026Article
- Relative contribution of driving pressure and respiratory rate to mortality in ARDS depends on age.American journal of respiratory and critical care medicine · 2026Article
- Encephalopathy in mechanically ventilated adult patients in the intensive care unit: the role of β-Lactam overdosing.Scientific reports · 2026Article
- Association between opioid infusion use and duration of mechanical ventilation and related outcomes in critically ill adults: a systematic review and meta-analysis.Annals of intensive care · 2026Article
- Impact of dexmedetomidine administration on mortality in patients with cardiac arrest: a propensity score matching analysis of the MIMIC-IV database.Scientific reports · 2025Article
- Comparison of Propofol and Dexmedetomidine Infused Overnight to Treat Hyperactive and Mixed ICU Delirium: A Prospective Randomised Controlled Clinical Trial.Journal of clinical medicine · 2025Article
- Impact of perioperative dexmedetomidine treatment on 1-year mortality in patients undergoing orthotopic heart transplantation.BJA open · 2025Article
- Association of Dexmedetomidine With Postoperative Depressive Symptoms in Older Surgical Patients: A Prospective Multicenter Study.CNS neuroscience & therapeutics · 2025Observational
- Cost-Effectiveness of α2 Agonists for Intravenous Sedation in Patients With Critical Illness.JAMA network open · 2025Article
- Risk factors for in-hospital mortality in surgical patients with abdominal sepsis in China: a nested case-control study.BMJ open · 2025Article
- Reply to HuaAmerican journal of respiratory and critical care medicine · 2025Article
Corrections and comments
- Commented on by
Authors and funding
15 authors at 12 institutions in 7 countries.
Yahya ShehabiMonash Health School of Clinical Sciences and.
Ary Serpa NetoAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Rinaldo BellomoAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Belinda D HoweAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Yaseen M ArabiCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia.ORCID 0000-0001-5735-6241
Michael BaileyAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Frances E BassCritical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
Suhaini Bin KadimanDepartment of Anesthesiology and Intensive Care, IJN-UTM Cardiovascular Engineering Center, National Heart Institute, Kuala Lumpur, Malaysia.
Colin J McArthurDepartment of Critical Care Medicine, Auckland City Hospital, University of Auckland, Auckland, New Zealand.
Michael C ReadeFaculty of Medicine, University of Queensland, Royal Brisbane and Women's Hospital, Brisbane, Australia.
Ian M SeppeltSydney Medical School-Nepean, University of Sydney, Sydney, New South Wales, Australia.
Jukka TakalaDepartment of Intensive Care Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.
Matt P WiseAdult Critical Care, University Hospital of Wales, Cardiff, United Kingdom; and.
Steve A WebbAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
SPICE III Study Investigators
Monash University · AUThe University of Melbourne · AUKing Saud bin Abdulaziz University for Health Sciences · SAMonash Health · AUNational Heart Institute · MYRoyal North Shore Hospital · AURoyal Perth Hospital · AUThe University of Queensland · AUThe University of Sydney · AUUniversity Hospital of Wales · GBUniversity of Auckland · NZUniversity of Bern · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
DexmedetomidinePropofolCohort StudiesCritical IllnessHumansHypnotics and SedativesRespiration, ArtificialDexmedetomidineHypnotics and SedativesPropofolage groupsintensive caremechanical ventilationrespiratorysedative effect
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.