Evidence map›Paper›PMID 36215116›Full record

ArticleThe European journal of neuroscience2024

Sleep and wake in a model of the thalamocortical system with Martinotti cells.

Tom Bugnon, William G P Mayner, Chiara Cirelli, Giulio Tononi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European journal of neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tom BugnonDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-2951-7903
William G P MaynerDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Chiara CirelliDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-2563-677X
Giulio TononiDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
University of Wisconsin–Madison · US

Funding

NEUROSCIENCE TRAINING PROGRAMT32GM007507 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HALLORAN, MARY C · 1985 to 2017
$9.3M
Electron Microscopy Core CP01NS083514 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI CIRELLI, CHIARA · 2014 to 2018
$7.7M
NIH Director's Pioneer Award (RMI)DP1OD000579 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI TONONI, GIULIO · 2005 to 2009
$3.6M
The cost of plasticity: from cells to systemsR01MH099231 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI CIRELLI, CHIARA, TONONI, GIULIO · 2013 to 2017
$3.3M
Synapses and Sleep in Neurodevelopment: A Crucial Interaction at a Critical TimeR01MH091326 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI CIRELLI, CHIARA, TONONI, GIULIO · 2010 to 2014
$3.2M
Cortico-thalamic mechanisms of anesthetic unconsciousnessR01GM116916 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BANKS, MATTHEW I, TONONI, GIULIO · 2016 to 2019
$1.8M
NIGMS NIH HHS R01 GM116916NIGMS NIH HHS T32 GM007507NIH HHS DP1 OD000579NIMH NIH HHS R01 MH091326NIMH NIH HHS R01 MH099231NINDS NIH HHS P01 NS083514
6 · The paper itself

Abstract

The mechanisms leading to the alternation between active (UP) and silent (DOWN) states during sleep slow waves (SWs) remain poorly understood. Previous models have explained the transition to the DOWN state by a progressive failure of excitation because of the build-up of adaptation currents or synaptic depression. However, these models are at odds with recent studies suggesting a role for presynaptic inhibition by Martinotti cells (MaCs) in generating SWs. Here, we update a classical large-scale model of sleep SWs to include MaCs and propose a different mechanism for the generation of SWs. In the wake mode, the network exhibits irregular and selective activity with low firing rates (FRs). Following an increase in the strength of background inputs and a modulation of synaptic strength and potassium leak potential mimicking the reduced effect of acetylcholine during sleep, the network enters a sleep-like regime in which local increases of network activity trigger bursts of MaC activity, resulting in strong disfacilitation of the local network via presynaptic GABA

Indexed as

Cerebral CortexSleepElectroencephalographyNeuronscomputational modellarge-scale simulationMartinotti cellssleepslow wavesomatostatin-positive cellsvisual cortexwake

Identifiers

PMID36215116
PMCPMC10083195
OpenAlexW4304080539

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.