Evidence map›Paper›PMID 36214945›Full record

Trial reportSleep & breathing = Schlaf & Atmung2023

Correlates of cognition among people with chronic heart failure and insomnia.

Jacqueline H Geer, Sangchoon Jeon, Meghan O'Connell, Sarah Linsky, Samantha Conley, Christopher S Hollenbeak, Daniel Jacoby, H Klar Yaggi, Nancy S Redeker

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jacqueline H GeerYale School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.
Sangchoon JeonYale School of Nursing, 400 West Campus Drive, Orange, CT, 06477, USA.
Meghan O'ConnellSchools of Nursing and Medicine, University of Connecticut, 231 Glenbrook Road, Unit 4026, Storrs Mansfield, CT, 06269, USA.
Sarah LinskyYale School of Nursing, 400 West Campus Drive, Orange, CT, 06477, USA.
Samantha ConleyMayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Christopher S HollenbeakPennsylvania State University, Donald H. Ford Bldg, University Park, PA, 16802, USA.
Daniel JacobyYale School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.
H Klar YaggiYale School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.
Nancy S RedekerYale School of Nursing, 400 West Campus Drive, Orange, CT, 06477, USA. nancy.redeker@uconn.edu.ORCID 0000-0001-7817-2708
Yale University · USUniversity of Connecticut · USMayo Clinic · USPennsylvania State University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Rest Activity Rhythms and Cognitive Function in Stable Heart FailureR01NR016191 · NINR · YALE UNIVERSITY · PI REDEKER, NANCY S · 2015 to 2019
$3.6M
Yale Center for Sleep Disturbance in Acute and Chronic ConditionsP20NR014126 · NINR · YALE UNIVERSITY · PI KRYGER, MEIR H, YAGGI, HENRY KLAR · 2012 to 2016
$1.4M
NCATS NIH HHS KL2 TR001862NCATS NIH HHS UL1 TR001863NIH HHS R01NR016191NINR NIH HHS P20 NR014126NINR NIH HHS R01 NR016191
6 · The paper itself

Abstract

purposeThis study aimed to describe cognitive characteristics and their associations with demographic and clinical factors among adults with chronic heart failure (HF) and insomnia.

methodsWe performed a cross-sectional analysis of baseline data from the HeartSleep Study (NCT#02,660,385), a randomized controlled trial designed to evaluate the effects of cognitive-behavioral therapy for insomnia. Demographic characteristics and health history were obtained. We measured sleep characteristics with the Insomnia Severity Index, the PROMIS Sleep Disturbance Questionnaire, and wrist actigraphy. Sleepiness, stress, and quality of life were measured with validated questionnaires. Measures of cognition included frequency of lapses on the psychomotor vigilance test and the PROMIS cognitive abilities scale where ≥ 3 lapses and a score of ≤ 50, respectively, suggested impairment. These variables were combined into a composite score for multivariable analyses.

resultsOf a sample that included 187 participants (58% male; mean age 63.1 [SD = 12.7]), 77% had New York Heart Association class I or II HF and 66% had HF with preserved ejection fraction. Common comorbidities were diabetes (35%), hypertension (64%), and sleep apnea (54%). Impaired vigilant attention was associated with non-White race, higher body mass index, less education, and more medical comorbidities. Self-reported cognitive impairment was associated with younger age, higher body mass index, and pulmonary disease. On adjusted analysis, significant risk factors for cognitive impairment included hypertension (OR 1.94), daytime sleepiness (OR 1.09), stress (OR 1.08), and quality of life (OR 0.12).

conclusionsImpaired cognition is common among people with chronic HF and insomnia and associated with hypertension, daytime sleepiness, stress, and poor quality of life.

trial registrationClinicalTrials.gov Identifier: Insomnia Self-management in Heart Failure; NCT#02,660,385.

Indexed as

Disorders of Excessive SomnolenceHeart FailureHypertensionSleep Initiation and Maintenance DisordersAdultChronic DiseaseCognitionCross-Sectional StudiesFemaleHumansMaleMiddle AgedQuality of LifeCognitive dysfunctionHeart failureHypertensionInsomniaSleep apnea

Identifiers

PMID36214945
PMCPMC10084469
OpenAlexW4304003390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.