Evidence map›Paper›PMID 36214883›Full record

Trial reportEuropean journal of clinical pharmacology2022

Evaluation of drug interactions of saxagliptin with sildenafil in healthy volunteers.

Rania Y Mansour, Radwa ElBorolossy, Sara M Shaheen, Nagwa A Sabri

Registry-linked trialOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04170790 (Evaluation of Drug Interactions of Saxagliptin With Sildenafil in Healthy Volunteers), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04170790 naunknown statusnot on this map

Evaluation of Drug Interactions of Saxagliptin With Sildenafil in Healthy Volunteers

TypeinterventionalSponsorAin Shams UniversityRan2019 to 2020Enrolled18ConditionsDiabetes Mellitus, Type 2, Erectile Dysfunction With Diabetes Mellitus, Drug InteractionArmsSaxagliptin 5mg, Sildenafil 50 mg
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rania Y MansourMScs. Of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Radwa ElBorolossyClinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Radwa.abdelkader@pharma.asu.edu.eg.ORCID http://orcid.org/0000-0003-3868-7832
Sara M ShaheenClinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Nagwa A SabriClinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.ORCID http://orcid.org/0000-0002-2611-4853
Ain Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study is to investigate the effect of sildenafil a CYP3A4 substrate and inhibitor on the pharmacokinetics and safety of saxagliptin.

methodsEighteen healthy volunteers were recruited in sequential; single-center study to determine pharmacokinetic parameters of saxagliptin and sildenafil, and (AUC

resultsSaxagliptin ratios of T/R and 90% CI were 132.1% (122.7-142.3) for AUC

conclusionSildenafil significantly affected the pharmacokinetic parameters of saxagliptin when co-administered. REGISTRATION: This trial was registered at clinicaltrials.gov under identifier number: [NCT04170790] in November 2019.

Indexed as

Tandem Mass SpectrometryAdamantaneArea Under CurveChromatography, LiquidCross-Over StudiesDipeptidesDrug InteractionsHealthy VolunteersHumansSildenafil CitrateAdamantaneDipeptidessaxagliptinSildenafil CitrateDiabetesDrug interactionsPharmacodynamicsPharmacokineticsSaxagliptinSexual dysfunctionSildenafil

Identifiers

PMID36214883
PMCPMC9549831
OpenAlexW4304014702

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.