SynthesisJournal of endovascular therapy : an official journal of the International Society of Endovascular Specialists2024
Carotid Artery Stenting With Double-Layer Stent: A Systematic Review and Meta-Analysis.
Synthesis in Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Comparing the Impact of Stenting vs. Medical Therapy for Intracranial Arterial Stenosis : A Systematic Review and One-stage and Two-stage Meta-Analysis of Randomized Clinical Trials.Clinical neuroradiology · 2024Pooled it
- Plaque Prolapse in Carotid Artery Stenting: Mechanisms, Imaging and Device-Based Prevention.Medicina (Kaunas, Lithuania) · 2026Review
- Carotid artery stenting with dual-layer stent implantation in a patient with complex anatomy.Jornal vascular brasileiro · 2026Article
- 30-Day Outcomes of Real-World Elective Carotid Stenosis Treatment Using a Dual-Layer Micromesh Stent (ROADSAVER Study).Cardiovascular and interventional radiology · 2025Observational
- Use of Double-Layer Carotid Stents Is Associated with Improved Patient Survival and Lower Neurological Complications: A Single-Center Retrospective Observational Study.Journal of clinical medicine · 2025Article
- Carotid Artery Geometry Modifications and Clinical Implications after Carotid Artery Stenting.Journal of personalized medicine · 2024Article
- Mid-Term Results of an Italian Multicentric Experience with the RoadsaverHealthcare (Basel, Switzerland) · 2024Article
- Subacute In-Stent Occlusion 2 Weeks after CASPER Rx Stenting: A Case Report.Journal of neuroendovascular therapy · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarotid artery stenting (CAS) in the treatment of significant stenosis is a cause of stroke due to both plaque prolapse and cerebral embolization. New types of stents with a double-layer structure have been designed to minimize plaque prolapse and embolization; these double-layer stents (DLSs) should be able to reduce the stroke risk; however, definite data on their performance are scarce in the literature.
methodsA systematic search was performed through PubMed, Scopus, and Cochrane Library, according to PRISMA guidelines; all studies on CAS with DLS (Roadsaver/Casper or CGuard) up to January 1, 2022, with a cohort of at least 20 patients were considered eligible. The present meta-analysis was approved and registered on PROSPERO register (CRD42022297512). Patients with tandem lesions or complete carotid occlusion were excluded from the study. The 30-day stroke rate after CAS was analyzed evaluating the preoperative symptomatic status and DLS occlusion. The estimated pooled rate of events was calculated by random effect model and moderators were evaluated.
resultsA total of 14 studies were included in the meta-analysis for a total of 1955 patients. The estimated overall (95% confidence interval [CI]) stroke rate was 1.4% (0.9%-2.2%,
conclusionThe overall 30-day stroke rate in CAS with DLS is low (1.4%), with similar results in symptomatic and asymptomatic patients. Acute occlusion of DLS is rare (0.8%). Further studies are necessary to reduce the publication bias for asymptomatic patients. CLINICAL IMPACT: CAS with DLS is associated to a low rate of 30-day stroke in both symptomatic (1.9%) and asymptomatic (1.5%) patients. The type of DLS (CGuard or Roadsaver/Casper) did not affect the 30-day stroke rate.
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