Evidence map›Paper›PMID 36214126›Full record

ArticleStroke2022

Trends in 1-Year Recurrent Ischemic Stroke in the US Medicare Fee-for-Service Population.

Erica C Leifheit, Yun Wang, Larry B Goldstein, Judith H Lichtman

Abstract read
In one paragraph

Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Erica C LeifheitDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT (E.C.L., J.H.L.).ORCID 0000-0001-9675-8913
Yun WangSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT (Y.W.).
Larry B GoldsteinDepartment of Neurology, University of Kentucky College of Medicine and Kentucky Neuroscience Institute, Lexington (L.B.G.).ORCID 0000-0001-7747-128X
Judith H LichtmanDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT (E.C.L., J.H.L.).ORCID 0000-0001-5362-3875

Funding

Disparities in Patterns of Recurrent Stroke in the ElderlyR01AG056628 · NIA · YALE UNIVERSITY · PI JUDITH H LICHTMAN · 2018 to 2026
$5.6M
NIA NIH HHS R01 AG056628
6 · The paper itself

Abstract

backgroundThere have been important advances in secondary stroke prevention and a focus on healthcare delivery over the past decades. Yet, data on US trends in recurrent stroke are limited. We examined national and regional patterns in 1-year recurrence among Medicare beneficiaries hospitalized for ischemic stroke from 2001 to 2017.

methodsThis cohort study included all fee-for-service Medicare beneficiaries aged ≥65 years who were discharged alive with a principal diagnosis of ischemic stroke from 2001 to 2017. Follow-up was up to 1 year through 2018. Cox models were used to assess temporal trends in 1-year recurrent ischemic stroke, adjusting for demographic and clinical characteristics. We mapped recurrence rates and identified persistently high-recurrence counties as those with rates in the highest sextile for stroke recurrence in ≥5 of the following periods: 2001-2003, 2004-2006, 2007-2009, 2010-2012, 2013-2015, and 2016-2017.

resultsThere were 3 638 346 unique beneficiaries discharged with stroke (mean age 79.0±8.1 years, 55.2% women, 85.3% White). The national 1-year recurrent stroke rate decreased from 11.3% in 2001-2003 to 7.6% in 2016-2017 (relative reduction, 33.5% [95% CI, 32.5%-34.5%]). There was a 2.3% (95% CI, 2.2%-2.4%) adjusted annual decrease in recurrence from 2001 to 2017 that included reductions in all age, sex, and race subgroups. County-level recurrence rates ranged from 5.5% to 14.0% in 2001-2003 and from 0.2% to 8.9% in 2016-2017. There were 76 counties, concentrated in the South-Central United States, that had the highest recurrence throughout the study. These counties had populations with a higher proportion of Black residents and uninsured adults, greater wealth inequity, poorer general health, and reduced preventive testing rates as compared with other counties.

conclusionsRecurrent ischemic strokes decreased over time overall and across demographic subgroups; however, there were geographic areas with persistently higher recurrence rates. These findings can inform secondary prevention intervention opportunities for high-risk populations and communities.

Indexed as

Ischemic StrokeStrokeAdultAgedAged, 80 and overCohort StudiesFee-for-Service PlansFemaleHumansMaleMedicareUnited Statesischemic strokeMedicarepopulationrecurrencesecondary prevention

Identifiers

PMID36214126
PMCPMC11059192

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.