Evidence map›Paper›PMID 36214123›Full record

Observational studyCirculation. Heart failure2022

Health-Related Quality of Life in Older Patients With Heart Failure From Before to Early After Advanced Surgical Therapies: Findings From the SUSTAIN-IT Study.

Kathleen L Grady, Andrew Kao, John A Spertus, Eileen Hsich, Mary Amanda Dew, Duc-Thinh Pham, Justin Hartupee, Michael Petty, William Cotts, Salpy V Pamboukian and 12 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation. Heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02568930 (SUSTAIN-IT), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02568930 completednot on this map

SUSTAIN-IT: Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support?

TypeobservationalSponsorNorthwestern UniversityRan2015 to 2021Enrolled694ConditionsHeart Failure
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 15 institutions in 3 countries.

Kathleen L GradyNorthwestern University, Chicago, IL (K.L.G., D.-T.P., A.-C.A., C.E., A.B., C.Y.).ORCID 0000-0002-6570-5365
Andrew KaoSt. Luke's Medical Center, Kansas City, MO (A.K.).
John A SpertusUniversity of Missouri-Kansas City (J.A.S.).ORCID 0000-0002-2839-2611
Eileen HsichCleveland Clinic, OH (E.H.).ORCID 0000-0001-6420-0480
Mary Amanda DewUniversity of Pittsburgh, PA (M.A.D.).
Duc-Thinh PhamNorthwestern University, Chicago, IL (K.L.G., D.-T.P., A.-C.A., C.E., A.B., C.Y.).ORCID 0000-0003-4443-601X
Justin HartupeeWashington University, St. Louis, MO (J.H.).
Michael PettyUniversity of Minnesota Medical Center, Minneapolis (M.P.).
William CottsAdvocate Christ Medical Center, Oak Lawn, IL (W.C.).
Salpy V PamboukianUniversity of Alabama-Birmingham (S.V.P., J.K.K.).
Francis D PaganiUniversity of Michigan, Ann Arbor (F.D.P.).
Brent LampertOhio State University, Columbus (B.L.).
Maryl JohnsonUniversity of Wisconsin, Madison (M.J., M.M.).
Margaret MurrayUniversity of Wisconsin, Madison (M.J., M.M.).ORCID 0000-0002-4306-5985
Koji TakedaColumbia University, New York, NY (K.T., M.Y.).ORCID 0000-0001-8263-1911
Melana YuzefpolskayaColumbia University, New York, NY (K.T., M.Y.).ORCID 0000-0003-4729-8943
Scott SilvestryFlorida Hospital, Orlando (S.S.).
James K KirklinUniversity of Alabama-Birmingham (S.V.P., J.K.K.).
Adin-Cristian AndreiNorthwestern University, Chicago, IL (K.L.G., D.-T.P., A.-C.A., C.E., A.B., C.Y.).
Christian ElenbaasNorthwestern University, Chicago, IL (K.L.G., D.-T.P., A.-C.A., C.E., A.B., C.Y.).
Abigail BaldridgeNorthwestern University, Chicago, IL (K.L.G., D.-T.P., A.-C.A., C.E., A.B., C.Y.).ORCID 0000-0002-1573-0554
Clyde YancyNorthwestern University, Chicago, IL (K.L.G., D.-T.P., A.-C.A., C.E., A.B., C.Y.).ORCID 0000-0001-7271-4166
Northwestern University · USUniversity of Alabama at Birmingham · USUniversity of Wisconsin–Madison · USAdventHealth Orlando · USAdvocate Christ Medical Center · USCleveland Clinic · USSaint Luke's Health System · USTakeda (United States) · USThe Ohio State University · USUniversity of Michigan · USUniversity of Minnesota Medical Center · USUniversity of Missouri–Kansas City · USUniversity of Pittsburgh · USWashington University in St. Louis · USYanan University Affiliated Hospital · CN

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Sustaining quality of life of the aged: Heart transplant or mechanical support?R01AG047416 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GRADY, KATHLEEN L · 2015 to 2019
$3.3M
NCATS NIH HHS UL1 TR001422NIA NIH HHS R01 AG047416
6 · The paper itself

Abstract

backgroundRestoring health-related quality of life (HRQOL) is a therapeutic goal for older patients with advanced heart failure. We aimed to describe change in HRQOL in older patients (60-80 years) awaiting heart transplantation (HT) with or without pretransplant mechanical circulatory support (MCS) or scheduled for long-term MCS, if ineligible for HT, from before to 6 months after these surgeries and identify factors associated with change.

methodsPatients from 13 US sites completed the EuroQol 5-dimension 3L questionnaire and Kansas City Cardiomyopathy Questionnaire-12 at baseline and 3 and 6 months after HT or long-term MCS. Analyses included univariate comparisons and multivariable linear regression.

resultsAmong 305 participants (cohort mean age=66.2±4.7 years, 78% male, 84% White, 55% New York Heart Association class IV), 161 underwent HT (n=68 with and n=93 without pretransplant MCS), and 144 received long-term MCS. From baseline to 3 months, EuroQol 5-dimension visual analog scale scores improved in HT patients without pretransplant MCS (54.5±24.3 versus 75.9±16.0,

conclusionsIn older heart failure patients, HRQOL improved from before to early after HT and long-term MCS. At 6 postoperative months, HRQOL of long-term MCS patients was lower than one or both HT groups. Understanding change in HRQOL from before to early after these surgeries may enhance decision-making and guide patient care. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT02568930.

Indexed as

Heart-Assist DevicesHeart FailureHeart TransplantationQuality of LifeAgedAged, 80 and overFemaleHumansMaleMiddle AgedSurveys and QuestionnairesTreatment Outcomedecision-makingheart failureheart transplantationmechanical circulatory supportquality of life

Identifiers

PMID36214123
PMCPMC9561242
OpenAlexW4304116092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.