Evidence map›Paper›PMID 36214093›Full record

ArticleImmunology and cell biology2023

Islet-specific CD8

Mirei Okada, Vivian Zhang, Jeniffer D Loaiza Naranjo, Bree J Tillett, F Susan Wong, Raymond J Steptoe, Anne-Sophie Bergot, Emma E Hamilton-Williams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology and cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Optimizing CD8Experimental hematology & oncology · 2024
    Review
  5. The immunology of type 1 diabetes.Nature reviews. Immunology · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mirei OkadaThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.ORCID 0000-0002-9198-1128
Vivian ZhangThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Jeniffer D Loaiza NaranjoThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Bree J TillettThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
F Susan WongDivision of Infection and Immunity and Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff, UK.
Raymond J SteptoeThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Anne-Sophie BergotThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Emma E Hamilton-WilliamsThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.ORCID 0000-0003-4892-3691

Funding

NIAID NIH HHS HHSN272201300006C
6 · The paper itself

Abstract

Type 1 diabetes (T1D) is caused by aberrant activation of autoreactive T cells specific for the islet beta cells. How islet-specific T cells evade tolerance to become effector T cells is unknown, but it is believed that an altered gut microbiota plays a role. Possible mechanisms include bystander activation of autoreactive T cells in the gut or "molecular mimicry" from cross-reactivity between gut microbiota-derived peptides and islet-derived epitopes. To investigate these mechanisms, we use two islet-specific CD8

Indexed as

Diabetes Mellitus, Type 1Islets of LangerhansAnimalsCD8-Positive T-LymphocytesEpitopesLymph NodesMicePeptidesEpitopesPeptidesautoimmunitybystander activationislet-specific T cellsmicrobiotamolecular mimicryType 1 diabetes

Identifiers

PMID36214093
PMCPMC10092732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.