Evidence map›Paper›PMID 36214089›Full record

ArticleJournal of separation science2022

Resolution, quantification, and reliable determination of enantiomeric excess of proteinogenic and non-proteinogenic amino acids by comprehensive two-dimensional gas chromatography.

Raphaël Pepino, Vanessa Leyva, Adrien D Garcia, Jana Bocková, Cornelia Meinert

Abstract read
In one paragraph

Article in Journal of separation science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Raphaël PepinoInstitut de Chimie de Nice, CNRS UMR 7272, Université Côte d'Azur, Nice, France.
Vanessa LeyvaInstitut de Chimie de Nice, CNRS UMR 7272, Université Côte d'Azur, Nice, France.ORCID https://orcid.org/0000-0003-3498-5736
Adrien D GarciaInstitut de Chimie de Nice, CNRS UMR 7272, Université Côte d'Azur, Nice, France.
Jana BockováInstitut de Chimie de Nice, CNRS UMR 7272, Université Côte d'Azur, Nice, France.ORCID https://orcid.org/0000-0003-3807-2491
Cornelia MeinertInstitut de Chimie de Nice, CNRS UMR 7272, Université Côte d'Azur, Nice, France.ORCID https://orcid.org/0000-0002-7256-2112

Funding

European Research Council 804144French Ministry of Science and Education
6 · The paper itself

Abstract

This work proposes a comprehensive two-dimensional gas chromatography method for the resolution and quantification of 27 amino acids, including 17 enantiomeric pairs, as stable N-trifluoroacetyl-O-methyl ester derivatives. The derivatization approach in combination with enantioselective two-dimensional gas chromatography has proven to be highly responsive with a method detection limit of 1-7 pg even for sterically hindered amino acids such as α,α-dialkylated, and N-alkylated amino acids. Accurate determination of the enantiomeric excess was achieved with errors in the range of ±0.5%-2.5% (1σ) at concentrations ≥10

Indexed as

Amino AcidsEstersChromatography, GasHumansMass SpectrometryStereoisomerismAmino AcidsEstersamino acidchiralityenantioseparationN-trifluoroacetyl-O-methyl estertwo-dimensional gas chromatography

Identifiers

PMID36214089
PMCPMC10092029

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.