Evidence map›Paper›PMID 36213999›Full record

ArticleJournal of Alzheimer's disease : JAD2022

Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.

Stefan Frenzel, Joshua C Bis, Elias F Gudmundsson, Adrienne O'Donnell, Jeannette Simino, Amber Yaqub, Traci M Bartz, Guy G O Brusselle, Robin Bülow, Charles S DeCarli and 30 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  8. Review
  9. Systemic determinants of brain health in ageing.Nature reviews. Neurology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 14 institutions in 4 countries.

Stefan FrenzelDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Elias F GudmundssonIcelandic Heart Association, Kopavogur, Iceland.
Adrienne O'DonnellFramingham Heart Study, Framingham, MA, USA.
Jeannette SiminoGertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
Amber YaqubDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Traci M BartzCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Guy G O BrusselleDepartment of Respiratory Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Robin BülowInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Charles S DeCarliDepartment of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA.
Ralf EwertDepartment of Internal Medicine B, Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Greifswald, Germany.
Sina A GharibCenter for Lung Biology, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
Saptaparni GhoshFramingham Heart Study, Framingham, MA, USA.
Monica Gireud-GossGlenn Biggs Institute for Alzheimer and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, SanAntonio, TX, USA.
Rebecca F GottesmanStroke, Cognition, and Neuroepidemiology (SCAN) section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Lenore J LaunerLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, NC, USA.
W T LongstrethDepartment of Neurology, University of Washington, Seattle, WA, USA.
Oscar L LopezDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Debora Melo van LentFramingham Heart Study, Framingham, MA, USA.
George O'ConnorFramingham Heart Study, Framingham, MA, USA.
Claudia L SatizabalGlenn Biggs Institute for Alzheimer and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, SanAntonio, TX, USA.
Srishti ShresthaGertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
Sigurdur SigurdssonIcelandic Heart Association, Kopavogur, Iceland.
Beate StubbeDepartment of Internal Medicine B, Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Greifswald, Germany.
Rajesh TalluriDepartment of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA.
Ramachandran S VasanFramingham Heart Study, Framingham, MA, USA.
Meike W VernooijDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Bing YuDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Alexa S BeiserFramingham Heart Study, Framingham, MA, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Thomas MosleyGertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Frank J WoltersDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Sudha SeshadriFramingham Heart Study, Framingham, MA, USA.
Boston University · USUniversitätsmedizin Greifswald · DEUniversity of Washington · USErasmus MC · NLUniversity of Mississippi Medical Center · USIcelandic Heart Association · ISNational Institutes of Health · USThe University of Texas Health Science Center at San Antonio · USMayo Clinic in Arizona · USNational Institute on Aging · USThe University of Texas Health Science Center at Houston · USUniversity of California, Davis · USUniversity of Iceland · ISUniversity of Pittsburgh · US

Funding

South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)RF1AG059421 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2018 to 2018
$6.1M
Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)R01AG059421 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Stephanie Anne-Carine Debette, Carole Dufouil · 2026 to 2026
$4.7M
NHLBI NIH HHS R01 HL105756NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG059421NIA NIH HHS RF1 AG059421NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

backgroundPrevious studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.

objectiveTo study the cross-sectional associations of pulmonary function with structural brain variables.

methodsData from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses.

resultsFEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume.

conclusionIn cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.

Indexed as

LungMagnetic Resonance ImagingAgedBrainCross-Sectional StudiesForced Expiratory VolumeHumansDementiaepidemiologymagnetic resonance imagingrespiratory function tests

Identifiers

PMID36213999
PMCPMC9712227
OpenAlexW4300981025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.