Evidence map›Paper›PMID 36213922›Full record

SynthesisFrontiers in psychiatry2022

The mirror mechanism in schizophrenia: A systematic review and qualitative meta-analysis.

Amir Valizadeh, Mathew Mbwogge, Anita Rasouli Yazdi, Nazanin Hedayati Amlashi, Ainaaz Haadi, Monir Shayestefar, Mana Moassefi

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amir ValizadehNeuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mathew MbwoggeIndependent Researcher, London, United Kingdom.
Anita Rasouli YazdiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Nazanin Hedayati AmlashiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ainaaz HaadiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Monir ShayestefarNeuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mana MoassefiNeuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mirror neuron system (MNS) consists of visuomotor neurons that are responsible for the mirror neuron activity (MNA), meaning that each time an individual observes another individual performing an action, these neurons encode that action, and are activated in the observer's cortical motor system. Previous studies report its malfunction in autism, opening doors to investigate the underlying pathophysiology of the disorder in a more elaborate way and coming up with new rehabilitation methods. The study of MNA function in schizophrenia patients has not been as frequent and conclusive as in autism. In this research, we aimed to evaluate the functional integrity of MNA and the microstructural integrity of MNS in schizophrenia patients. Methods: We included case-control studies that have evaluated MNA in schizophrenia patients compared to healthy controls using a variety of objective assessment tools. In August 2022, we searched Embase, PubMed, and Web of Science for eligible studies. We used an adapted version of the NIH Quality Assessment of Case-Control Studies tool to assess the quality of the included studies. Evidence was analyzed using vote counting methods of the direction of the effect and was tested statistically using the Sign test. Certainty of evidence was assessed using CERQual. Results: We included 32 studies for the analysis. Statistical tests revealed decreased MNA ( Discussion: This finding contributes to gaining a better understanding of the underlying pathophysiology of the disorder by revealing its possible relation to some of the symptoms in schizophrenia patients, while also highlighting a new commonality with autism. Systematic review registration: PROSPERO identifier: CRD42021236453.

Indexed as

meta-analysismirror neuron activitymirror neuronsmirror neuron systemschizophreniaschizophrenia spectrum disordersystematic review

Identifiers

PMID36213922
PMCPMC9532849

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.