Evidence map›Paper›PMID 36213511›Full record

ArticlePeerJ2022

Effects of combination of obesity, diabetes, and hypoxia on inflammatory regulating genes and cytokines in rat pancreatic tissues and serum.

Sarah Albogami, Aziza Hassan, Sekena H Abdel-Aziem, Saqer Alotaibi, Fayez Althobaiti, Ahmed El-Shehawi, Alaa Alnefaie, Reem Abdulla Alhamed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sarah AlbogamiDepartment of Biotechnology, College of Science, Taif University, Taif, Saudi Arabia.
Aziza HassanDepartment of Biotechnology, College of Science, Taif University, Taif, Saudi Arabia.
Sekena H Abdel-AziemCell Biology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Cairo, Egypt.
Saqer AlotaibiDepartment of Biotechnology, College of Science, Taif University, Taif, Saudi Arabia.
Fayez AlthobaitiDepartment of Biotechnology, College of Science, Taif University, Taif, Saudi Arabia.
Ahmed El-ShehawiDepartment of Biotechnology, College of Science, Taif University, Taif, Saudi Arabia.
Alaa AlnefaieHigh Altitude Research Center, Taif University, Taif, Saudi Arabia.
Reem Abdulla AlhamedDepartment of Biotechnology, College of Science, Taif University, Taif, Saudi Arabia.
Taif University · SANational Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Obesity and diabetes are becoming increasingly prevalent around the world. Inflammation, oxidative stress, insulin resistance, and glucose intolerance are linked to both obesity and type 2 diabetes, and these disorders are becoming major public health issues globally. Methods: This study evaluated the effects of obesity, diabetes, and hypoxia on the levels of pro- and anti-inflammatory cytokines in rats. We divided 120 Wistar rats in two groups, male and female, each including six subgroups: control (CTRL), obese (high-fat diet (HFD)), diabetic (streptozotocin (STZ)-treated), hypoxic (HYX), obese + diabetic (HFD/STZ), and obese + diabetic + hypoxic (HFD/STZ/HYX). We examined the levels of tumor necrosis factor- Results: No significant difference was observed in serum levels of cholesterol, triglycerides, and low-density lipoprotein (LDL) between HYX and CTRL in either sex. However, they were significantly increased, whereas high-density lipoprotein (HDL) was significantly decreased in HFD, STZ, HFD/STZ, and HFD/STZ/HPX compared with CTRL in both sexes. The expression of

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2AnimalsCytokinesFemaleInflammationInterleukin-6MaleObesityRatsRats, WistarTumor Necrosis Factor-alphaCytokinesInterleukin-6Tumor Necrosis Factor-alphaCytokinesDiabetesGenesHypoxiaInflammatoryObesityPancreatic tissuesSerum

Identifiers

PMID36213511
PMCPMC9541627
OpenAlexW4301397258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.