ArticleBrain, behavior, & immunity - health2022
Adverse and traumatic exposures, posttraumatic stress disorder, telomere length, and hair cortisol - Exploring associations in a high-risk sample of young adult residential care leavers.
Article in Brain, behavior, & immunity - health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Associations of childhood maltreatment types and timing with oxidative stress in formerly out-of-home placed young adults.European journal of psychotraumatology · 2026Article
- Association between telomere length and psychiatric disorders: a bidirectional Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- A lifespan approach to biological aging: Early adversity, past-year trauma, and telomere length in women.Psychoneuroendocrinology · 2025Article
- Associations of lifetime stressors and health behaviors with inflammation in young adults previously placed in youth residential care.Brain, behavior, & immunity - health · 2025Article
- Differential effects of childhood maltreatment types and timing on psychopathology in formerly out-of-home placed young adults.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Post-traumatic stress disorder in older adults: a global collaboration on setting the future research agenda.The lancet. Healthy longevity · 2025Review
- Tracing mitochondrial marks of neuronal aging in iPSCs-derived neurons and directly converted neurons.Communications biology · 2025Article
- Telomere Dynamics in Post-Traumatic Stress Disorder: A Critical Synthesis.Biomedicines · 2025Review
- Childhood trauma is linked to epigenetic age deceleration in young adults with previous youth residential care placements.European journal of psychotraumatology · 2024Article
- Interplay between stress, sleep, and BDNF in a high-risk sample of young adults.Scientific reports · 2023Article
- Maternal stress-induced changes in adolescent and adult offspring: Neurobehavioural improvement and telomere maintenance.Heliyon · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Childhood adversities (CAs), potentially traumatic exposures (PTEs), and posttraumatic stress disorder (PTSD) are known to increase the risk for poor health outcomes, including diseases of aging and early mortality. Telomere length (TL) and hair cortisol concentrations (HCC) are biomarkers known to be associated with CA and PTEs, and PTSD, but there is considerable heterogeneity in findings. Objectives: This study aims to investigate the association of CAs, PTEs, and PTSD with TL and HCC in a high-risk sample of young adults who were previously placed in youth residential care institutions throughout Switzerland. Method: Our sample includes 130 participants (30.8% women, M Results: In our high-risk sample, a higher burden of CAs, PTEs, Criterion A trauma, and PTSD was associated with longer TL. PTEs, Criterion A trauma, and PTSD were associated with lower HCC, however no significant associations between CAs and HCC were found. The magnitude of these effects varied depending on the dimensional or categorical nature of the stress-phenotype and the specific measure used. Conclusions: Our findings are in contrast with many, but not all, previous studies of associations between adversity and both TL and HCC. For instance, our findings are in line with other studies that find a state of hypocortisolism in PTSD. Better measurement of adversities and trauma, multisystem biomarker approaches, and more research in larger high-risk samples at the upper end of the adversity-continuum is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.